聚合物纳米材料的微纳结构决定了其性能及应用前景。随着纳米材料的广泛应用，发展新型自组装技术，实现聚合物微纳结构的精细调控是纳米领域的一个重大挑战，并且有待更深入地研究。本项目拟建立聚合物限域共混纳米沉淀的自组装行为规律及机理，实现有序、多样和稳定的聚合物微纳结构调控。本项目将系统研究微观混合动力驱使下，组装基元相互作用的协同效应及机制；发展流动过程化学反应与自组装同步耦合的多级多组分构建能力；高效高选择性地构建不同尺度和形貌的聚合物有序组装体。本项目旨在有机地结合流动和自组装过程，发展加速组装的新理论和新方法，为快速、高效、多层次构建聚合物微纳结构提供新途径。因此，本项目不仅是对自组装理论的丰富，也将为聚合物纳米材料的快速可控制备提供崭新的技术手段。

Micro-/nano-structure has exerted a great impact on the functionality and applications of polymer nanoparticles (NPs). The challenge in the preparation of polymer NPs is to find a simple, cost-effective and less time-consuming technique with tunable ability in structure construction. Here, we seek to advance a novel nanomanufacturing process, termed Confined Mixing Induced Nanoprecipitation (CMIN), to generate polymer NPs with broad tunability. In this proposal, we will systematically pursue solutions to study the nanoprecipitation process, including the physics of self-assembly, hierarchical behavior of combining chemical reaction with self-assembly and evolution of nanostructure. This work will lead to a greater understanding of nanoscale polymer self-assembly during the process of CMIN, as well as construct a broad range of polymer with precisely controlled structures. Therefore, this project will not only develop a novel self-assembly theory, but also provide a versatile strategy to produce polymer NPs with efficiency required to realize their technological potential.