安非他明类兴奋剂滥用严重，既影响国民经济发展，危害人民身心健康，又诱发各种犯罪活动。而当前，基于昂贵仪器的检测方法，难以满足安非他明类兴奋剂低成本和快速检测的需求。为克服这一困难，本项目力求探索发光金属-有机框架（LMOFs）作为传感材料检测安非他明类兴奋剂，并以此为基础进行机理分析，为发光配位聚合物检测安非他明类兴奋剂的研究提供实践和理论支撑。具体研究内容叙述涵括三个方面：(1)合成LMOFs材料，研究降低MOFs导带的方法；(2)分别在液相和气相环境下，对三种主要的安非他明类兴奋剂进行荧光传感检测；(3)基于LMOFs和被检测分子的结构、轨道（导带或LUMO）、荧光变化效应等，分析荧光传感机理，提出高性能LMOFs传感材料设计策略。项目申请人在MOFs材料合成和表征方面具有丰富经验，所在部门拥有成熟的毒品研究平台，预期将在安非他明类兴奋剂快速检测研究上取得突破。

The abuses of amphetamine-type stimulants are serious, which not only impact the development of national economy and endanger people’s physical and mental health, but also induce various criminal activities. However, the current dection methods of amphetamine-type stimulants based on sophisticated instruments are difficult to match the requirements during the dection of amphetamine-type stimulants, such as lowcost and speediness. In order to overcome this difficulty, luminescent metal-organic frameworks (LMOFs) as sensory materials for the detection of amphetamine-type stimulants are presented in this project. In-depth discussion will be imposed on the mechanism of sensing process. The project is expected to provide practical and theoretical support to the research of LMOFs based senors detect amphetamine-type stimulants. The specific research content includes three aspects: (1) the synthesis of LMOFs and the methods to decrease conduction band (CB) of MOFs, (2) luminescence based sensing on three dominating amphetamine-type stimulants in liquid and gas phase respective, (3) based on architectural feature, CB of LMOF, LUMO orbital of analyte and the change of luminescence emission of LMOF, the mechanism analysis of luminescence sensing process will be discussed deeply to raise design strategies on LMOFs for highly selective detection of amphetamine-type stimulants. The project applicant has rich experience in synthesis and characterization of metal-organic frameworks materials, and works in a department with a mature drug research platform. A breakthrough is anticipative in the research of rapid detection of amphetamine-type stimulants.