部分性癫痫是一类具有遗传倾向的多基因复杂性疾病，其临床表型多种多样，由遗传和环境因素共同影响着疾病的发生和发展，但其具体的发病机制尚未完全明确。研究表明，表观遗传学是重要的基因表达调控模式，其中DNA甲基化与部分性癫痫的发生发展密切相关。本项目拟应用表观基因组关联研究（EWASs）策略，采用Infinium@Human Methylation45芯片从全基因组范围内探讨部分性癫痫患者DNA甲基化模式，筛选癫痫相关的关键基因或位点。从系统生物学的角度出发，选用基于通路的甲基化数据分析，预测可能改变的蛋白结构和功能及影响的信号通路，从表观遗传学层面探讨关键基因甲基化对癫痫的影响，以揭示部分性癫痫发生的表观遗传学机制，并试图筛选到甲基化标志物，从而为进一步探讨癫痫发生的分子机制提供实验依据。

Partial epilepsy is a multi-gene complex disease with obvious genetic predisposition. Its clinical phenotype is extremely manifold affected by a variety of genetic and environmental factors and the specific pathogenesis is not clear. Studies have shown that epigenetics is a more important mechanism of regulation of gene expression, DNA methylation is closely related to the development of epilepsy. This study intends to adopt the strategy based on Epigenome Association Research (EWASs) to study the characteristics and differences of partial epilepsy patients' nuclear pedigrees DNA methylation mode within ultimately whole genomes using Infinium@Human Methylation45 chip, and to screen key genes or loci related to epilepsy. Pathway based methylation data analysis method would be used to predict the structure,function and signal pathway of protein that may be changed from the perspective of systems biology, and then to discuss the influence of the key gene methylation on epilepsy from the view of epigenetics to reveal the epigenetic mechanisms during epileptogenesis. We attempt to get filtered methylation markers to provide experimental evidence for revealing the molecular mechanism of epilepsy.