高强度聚焦超声（HIFU）无创治疗肿瘤已展示出良好前景，但治疗剂量学仍然是HIFU治疗亟待解决的一个重要科学问题。立足前期研究基础，拟通过理论模拟和离体/活体实验验证相结合，建立HIFU治疗的非线性声传播与生物传热相互耦合模型，在这个模型中，考虑热波效应和空化/沸腾产生的气泡对传热的影响，进而对Pennes生物传热方程进行修正，又考虑随温度变化的组织声特性、气泡对非线性声传播的影响，进而对温场的影响。在此基础上，利用理论模拟和MRI测温获得的温度场，研究获得不同HIFU辐照方式下的热剂量（CEM43°），并探讨空化剂量和血流灌注指数对CEM43°C的影响。通过研究，可望获得更多针对HIFU治疗的非傅里叶传热、声热耦合特别是聚焦声场与气泡相互作用的知识，挑战采用热疗的等效热剂量不适合HIFU剂量学研究问题，为研究HIFU治疗剂量学提供科学依据，助推HIFU 技术及其产业和相关学科发展。

It has been demonstrated that high intensity focused ultrasound (HIFU) as a noninvasive tumor treatment modality has promising potential. But the dosimetry is still a key scientific issue for HIFU non-invasive treatment needed to be solved. Based on the preliminary achievements in development of HIFU device，clinical application and many basic researches, this project is aimed at establishing an acoustic-thermo coupling model incorporating the nonlinear propagation of ultrasound and bioheat transfer via the combination of theoretical simulation and validation experiments in vivo and vitro. In the present model, on the one hand the thermal wave effect and influence of cavitation/boiling bubbles for bioheat transfer are considered to modify the Pennes bioheat transfer equation, the other hand the temperature-dependant tissue properties in HIFU irradiation and the influence of cavitation/boiling bubbles for nonlinear acoustic propagation even for the temperature field are considered. On the basis of above, according to the temperature field obtained from theoretical simulation and MRI measurement, we can get the thermal dose(CEM43°) in different mode of HIFU irradiation, and explore the influence of cavitation dose and blood perfusion index for CEM 43°.By the study of present project, it is promising to get more knowledges about non-Fourier heat transfer in HIFU treatment and acoustic thermal coupling especially the interaction of HIFU acoustic field and bubbles. In addition, we will challenge the problem that the equivalent thermal dose in hyperthermia is not appropriate to determine the thermal dose distribution with HIFU irradiation, in order to investigate the dosimetry in HIFU, and furthermore to provide scientific basis for assessment of HIFU damage accurately and quantitatively, thus promoting the further development of HIFU technology and its relevant disciplines to keep our advanced fore front position in the world.