HIFU无创治疗肿瘤展示出良好前景。空化/沸腾泡在HIFU治疗中扮演着重要角色，而目前的研究多以检测到的声信号来推断HIFU声场下气泡活动的动力学规律，且其结论基于各自的HFU辐照参数，难以阐明不同HIFU辐照方式下的复杂治疗机制，同时缺乏不同HIFU声场下气泡动力学行为的动态/瞬态和稳态可视佐证。在前期研究基础上，本项目以仿组织透明体模/牛眼晶状体为可视对象，采用主/被动空化检测、可听声检测和温度测量手段，并结合长焦距显微高速摄像，实验研究结合理论模拟，研究单纯热损伤、空化损伤、热和空化伴生三种HIFU辐照方式下焦域处沸腾泡和或空化泡产生前、产生瞬间、产生后在HIFU声场作用下的动态/瞬态和稳态动力学行为及其激发的特征声信号，以及HIFU声场下热、空化、空化/沸腾泡发生时序与相互作用规律，以期阐明HIFU治疗的热生物物理、声空化和气泡动力学机制，促进HIFU 技术及其产业和相关学科发展。

It has been demonstrated that high intensity focused ultrasound (HIFU) as a noninvasive tumor treatment modality has promising potential. Both acoustic cavitation and tissue boiling play an important role in the treatment. Currently researchers often use the detected acoustic signal to derive the dynamic law related to cavitating bubbles. It is difficult to state clearly the complex mechanism of the treatment for various sonication modes and it lacks the convincing evidence to distinguishing stable and transient cavitation processes. This project proposes to use tissue phantoms and bovine lenses as transparent and visible targets. In terms of technology, we will incorporate the long-focal length fast speed camera with active and passive cavitation detecting techniques, making the detecting signal both visible and audible. Therefore, we can study the ultrasound thermal effect, cavitation effect and thermal and cavitation combined effects in the focal zone and understand thoroughly the mechanisms of thermal biophysics, acoustic cavitation and bubble dynamics relevant to HIFU treatment. Our goal is to promote the further development of HIFU technology and its relevant disciplines to keep our advanced fore front position in the world.