Nd:YAG激光光热凝固术是口腔颌面部静脉畸形（venous malformations,VMs）治疗的重要手段。激光脉宽、能量、治疗时间和表面冷敷量等参数选择是否合理是决定治疗效果的关键，也是临床中亟需解决的重要问题。基于激光组织相互作用研究的温度场和热损伤建模是预测评估疗效和副作用的有效方法。本项目针对临床激光参数最优化的迫切需求，重点解决血液光热凝固光学和热物性参数动态改变问题，研究由数学模型、离体模型和动物模型所组成的临床实际温度场和热损伤精确预测评估系统。本项目以激光照射VMs所致温度场和热损伤研究为主线；以光学仿体、动物模型研究为桥梁；建立Nd:YAG激光与VMs相互作用基础研究与临床治疗效果之间的关系。最终研制一套具有自主知识产权、使用方便、性能优异的Nd:YAG激光治疗口腔颌面部VMs临床评估预测系统，从而为构建多学科交叉的脉管性疾病激光治疗研究平台和临床诊疗模式奠定基础。

Nd:YAG laser photocoagulation is an important treatment for venous malformations (VMs) in oral and maxillofacial regions. For enhancing the prognosis and avoiding side effects, doctors have been facing a great challenge on choosing suitable laser parameters which including the width and energy of laser pulse, irradiation time, the temperature and lasting time of cooling and so on. Temperature field and thermal damage model which based on the laser-tissue interaction research is an effective method for the evaluation of prognosis and side effects after laser therapy. The aim of this study is fulfilling the demands of laser parameters’ optimization. The key point of this study is clarification of the optical and themophysical parameters’ dynamic changes during blood photocoagulation. The anticipated results of this interdisciplinary study is the invention of precise method for the evaluation of temperature field and thermal damage which composed of numerous simulation, in vitro model and animal model. The main line of this study is temperature field and thermal damage research of VMs in oral and maxillofacial regions irradiated by Nd:YAG laser with different parameters. The relationship between fundamental study of Nd:YAG laser irradiating effects on VMs in oral and maxillofacial regions and clinical prognosis by the research of optical phantom and animal model. The inventions with intellectual property rights from above studies will be applied to establish a novel system with convenient usage and excellent performance in the prediction and evaluation of the VMs prognosis after Nd:YAG laser treatment with various laser parameters. And thus, a multidisciplinary research platform and novel clinical mode of laser therapy for vascular anomalies will be feasibility on the basis of this study.