外伤性视神经病变(Traumatic optic neuropathy，TON)是头面部外伤后视功能损害的重要原因之一，是当今主要致盲眼外伤之一。作为中枢神经系统的重要组成，加之其独特的解剖特点，目前对外伤性视神经损伤尚无确切有效疗法。因此，探索外伤性视神经损伤神经保护和再生的新方法具有重要的临床意义。本项目拟在前期研究基础之上，设计一种具有轴突定向诱导功能的三维神经支架，以生物相容性良好的乙交酯丙交酯共聚物（PLGA）、巯基化明胶(GE-SH)和巯基化透明质酸（HA-SH）等生物材料为基体，通过微流体纺丝法构建取向神经支架，同时共同负载曲安奈德（TA）和盐酸法舒第尔（FA），在保护RGCs的同时，在视神经损伤局部构建适宜的生物学微环境，对受损视神经进行损伤修复和再生促进。本项目有助于揭示支架和药物对视神经生存、凋亡及轴突再生的作用规律，为外伤性视神经损伤提供一种新的治疗策略。

Traumatic optic neuropathy (TON) describes an injury to the optic nerve following either blunt or penetrating trauma. TON remains an important cause of vision loss and no generalized clinical treatment has been established till now. Therefore, developing new approaches to protect injured optic nerve in TON and promote axonal regeneration of retinal ganglion cells (RGCs) is of great clinical and social value. Inspired by our previous research, we plan to fabricate a multi-functional drug-loaded nerve scaffold via microfluidic spinning method to treat complicated problem exists in TON, such as: inflammation, depressive micro-environment and so on. Poly(DL–lactide-Co-Glycolide), thiolated gelatin and thiolated hyaluronic acid will be adopted to construct drug carrier for Triamcinolone acetonide and Fasudil Hydrochloride to control inflammation and create permissive micro-environment for injured optic nerves, thus to preserve surviving RGCs and promote its axonal generation in oriented style. This project will help to make clear the effects of biomaterials and drugs on RGCs survival and regeneration and provide a promising strategy to treat TON in clinics.