病原物相关分子模式诱导的免疫（PTI）是植物抵抗病原物侵染的基础抗性之一，由蓟马传播的番茄斑萎病毒（TSWV）严重危害我国茄科作物。本项目的前期研究发现蓟马取食能激活植物的PTI，TSWV及其编码的NSs和N蛋白能抑制植物的PTI，而抑制PTI可以促进病毒的侵染，说明该病毒能抑制媒介昆虫诱导的PTI以促进自身的侵染。目前TSWV抑制植物PTI的分子机制还不清楚。本项目拟在前期工作基础上，明确TSWV抑制PTI对其复制和移动的影响，鉴定TSWV抑制PTI的效应蛋白，解析TSWV抑制PTI的分子机制，探明TSWV抑制PTI对介体传毒的生物学意义。研究结果不仅可以揭示TSWV乃至植物病毒抑制植物PTI免疫反应的分子机制，也将为植物-病毒-介体三者互作理论的研究提供思路和线索，为病害防控提供新的理论知识。

Pathogen-associated molecular patterns (PAMP)-triggered immunity (PTI) is a basal defense for plant to fight against pathogen invasion. Tomato spotted wilt virus (TSWV), which is transmitted thrips, causes serious disease in Solanaceae in China. Our preliminary studies found that thrip feeding induced PTI in plant and TSWV and its NSs and N protein could inhibit PTI in plant. Furthermore, TSWV infection was significantly enhanced in PTI deficient plant. Data above implies that TSWV promotes its infection through inhibiting thrip-induced PTI. The molecular mechanism of plant virus-performed PTI suppression is not known yet. This project intends to define the impact of suppressing PTI by TSWV on its replication and movement, to further identify TSWV encoded PTI suppressor(s), to reveal molecular mechanism of TSWV-performed PTI suppression and to explore the biological significance of TSWV inhibiting PTI on its transmission-mediated by thrip. The results of this project shall illustrate the molecular mechanism of plant virus-performed PTI suppression, provide ideas and clues for the study on plant-virus-vector interaction, and help to prevent and control TSWV-caused viral disease.