聚合诱导自组装（PISA）可以实现高固含量（高达50 wt%）和高级形态（蠕虫、囊泡等）的纳米自组装粒子的可控制备，活性阴离子聚合（LAP）可以实现新组成和新结构模型聚合物的精确合成，二者分别是前沿自组装技术和精确聚合技术的理想代表。本项目中，我们拟将LAP应用于PISA，开发PISA的新方法和新应用。拟通过筛选同时适合LAP和PISA的配方组合和优化聚合反应的影响因素，实现LAP-PISA中聚合和自组装过程的精确可控，提出LAP-PISA新方法。拟通过研究特殊结构的梯度聚合物和多分布聚合物的LAP-PISA，发展LAP-PISA新方法。拟通过研究LAP-PISA中纳米自组装粒子的稳定化和功能化修饰，拓展LAP-PISA的新应用。项目的顺利进展，将进一步丰富和完善高分子合成化学的方法学和高分子物理的自组装理论。

The nano-objects with high solids content (up to 50 wt %) and higher order morphologies (such as worms and vesicles) can be prepared by the polymerization-induced self-assembly (PISA) technique. The model polymers with various compositions and structures can be prepared by the living anionic polymerization (LAP) technique. Thus, the PISA and LAP have been recognized as the frontier self-assembly technique and well-controlled polymerization technique, respectively. In this project, the LAP will be introduced into the PISA, which would help to explore the synthetic route and potential application of PISA. Based on the selection of the formulations and the optimization of the factors, the LAP-PISA with well-controlled polymerization and self-assembly procedure will be studied. In order to further develop the LAP-PISA, the gradient and polydisperse copolymers with special structures will also be targeted. Finally, the formed nano-objects will be selectively stabilized and modified by some efficient reactions, and the potential applications will be preliminarily investigated. The successful progress in this project is expected to improve the development of the methodology in polymer chemistry and the self-assembly theory in polymer physics.