颅面部器官包括腭的发育是时间轴向上三维空间建立的连续过程，这涉及颅神经嵴细胞的粘附与迁徙的运动的平衡，而目前对其内在的机制并没有清晰的认识。我们前期研究发现Beta-catenin 参与颅颌面部区域化发育并贯穿始终，因此提出Beta-catenin可能在通过平衡颅神经嵴细胞粘附和区域化迁徙运动 起到重要的作用的假设。本研究首次通过建立动物 模型在发育时间轴上控制和干扰Beta-catenin 的表达，来观察Beta-catenin 如何平衡颅神经嵴粘附和区域化迁徙运动，以及在不同时间段对腭发育的影响, 同时通过检测与颅神经嵴迁徙，粘附及区域化相关的信号分子随Beta-catenin 表达的模式改变来尝试分析Beta-catenin 平衡颅神经嵴细胞粘附，区域化迁徙及对腭发育影响的内在机制，为进一步理解腭发育机制，腭裂的成因，探索新的早期预防手段提供理论支持。

How to organize the cells in their correct three-dimensional orientation is central to understanding craniofacial development including the.palatogensis. Particularly when tissue undergo a complex and intricate series of movement relative to each other as occurs in the developing craniofacial region. That means there needs a controlling mechanism to balance between cell adhesion and migration. Based on previous researches, B-catenin plays a key role in balancing cranial neural crest cells adhesion and migration. However, we still know little about the internal mechanisms. In this research, we try to address the question bycreating the b-catenin/over expression and knock-out mice models , additionally to observe how this effects the palatal development. Meanwhile, we will check the expression patterns changes of wnts, cadherins and ephrinb/ephb that related to cranial neural crest cells and palatogenesis and attempt to deduce the internal mechanisms that B-catenin is how to balance between cell adhesion and migration from the cranial neural crest cells to palatal processes. We wish our work could be helpful for further understanding palatogenesis and the causes of cleft palate, while providing some support for exploring new methods for early prevention in future.