不对称聚合物囊泡的构筑及其行为和功能

相对内外表面层由同一化学成分构筑的对称聚合物囊泡，内外表面层化学成分不同的不对称聚合物囊泡具有更加丰富的相态结构和行为。更重要的是不对称聚合物囊泡具有更好的选择吸附性、包覆性、以及单向通透性等。但是由于受能够形成囊泡的多嵌段聚合物样品的限制，人们对不对称聚合物囊泡的研究还相对很少，对其行为和功能的认识还十分有限。本项目针对具有更大选择范围的A-B/B-C两嵌段聚合物共混体系，应用计算机模拟和实验手段相结合研究共混物在选择性溶剂中的自组装和相行为，给出构筑不对称聚合物囊泡的窗口，揭示该类囊泡对环境响应及不同结构间转变的物理机制，并尝试给出该类聚合物囊泡对特定金属和生物纳米粒子的选择吸附性、包覆性和通透性以及这些性能与囊泡结构和相关环境因素的关系。

Compared to the symmetric polymer vesicle in which the inner and outer layers are constructed by same chemical component, the polymer vesicle with asymmetric layers exhibits richer phase structures and behaviors. More interestingly, such asymmetric polymer vesicles possess advanced properties in selective adhesion, encapsulation, permeability and so on. However, seldom asymmetric polymer vesicles have been studied due to the limit of multi block copolymer samples and their behaviors and functions need further understood. In this project, we focus on the A-B/B-C two diblock copolymer mixtures which can be selected in a wide range and use experiment and computer simulation to study their self-assembly and phase behavior in selective solvents. The purpose is to give the windows for constructing asymmetric polymer vesicles, reveal their environmental responses and phase structure transition mechanisms, and try to give their properties such as selective adhesion, encapsulation, permeability for some specified metal and protein nanoparticles and their relations with vesicle structure and related environmental factors.