本研究围绕现行方法是否适用于纳米材料遗传毒性的评价这一重要问题，而当前的研究思路难以提供有说服力的依据，提出拟采用可覆盖纳米材料可能的作用机制、从多遗传终点角度研究纳米材料遗传毒作用机制的胞质分裂阻滞法微核细胞组学等试验方法，对同一物质常规尺度与纳米尺度的遗传毒性进行比较研究的方法，对不同类型纳米材料的代表性物质进行深入研究，同时针对纳米材料关注的理化特性表征与遗传毒效应的关系进行研究，以揭示纳米材料的遗传毒作用特征。该研究可较充分、较深入地揭示纳米材料可能的遗传毒作用机制和毒作用特点，从而给现行评价体系是否适用于纳米材料遗传毒性评价这一重要问题的解决提供科学依据。因此，既有理论意义，又有重要的现实意义。

The study focuses on the significant problem whether the nanomaterials can be evaluated the characteristics of genotoxicity sufficiently using the current genotoxic testing methods or not. While it is nearly impossible to provide persuasive proof by the current study. Thus, our research is aimed to conduct comparative analysis of characteristics of genotoxicity for normal dimension and nano-dimension of the same material using cytokinesis-block micronucleus cytome assays which covers the potential mechanisms of actions for nanomaterials and can be applied to investigate the characteristics of genotoxicity for nanomaterials from many genetic end-points. Furthermore, characteristics of genotoxicity for representative nanomaterials of different types are thoroughly investigated using the above method, meanwhile the relationship between the physiochemical characters of nanomaterial and its genotoxicity are exploited to reveal the potential characteristics of genotoxicity. The study can thoroughly and adequately reveal the possible genotoxic mechanisms of actions and its characteristics, so it can provide scientific basis to solve the important problem whether the nanomaterials can be sufficiently evaluated the characteristics of genotoxicity with current genotoxic testing system. Therefore, it is worthy to be conducted theoretically and practically.