中医原创理论认为“心主神明”，其相关经脉心经心包经穴善治神志病。老龄化社会高发病阿尔茨海默病（AD）作为世界公共疑难问题备受瞩目。表观遗传学修饰与AD的密切关系是目前研究新热点，Aβ聚集沉积是AD发生发展过程中的关键机制，DNA甲基化在Aβ的生成、清除及毒性等相关基因表达的调控中发挥重要作用。结合最新前沿研究进展及本课题组前期研究成果，拟以AD重要靶点Aβ为切入点，以AD大鼠和AD细胞模型为观察对象，以电针心经心包经为干预手段，紧扣以Aβ生成、清除相关基因调控的甲基化修饰这一关键环节，利用前沿的RNA-seq、ChiP-seq及其他分子生物学、神经生物学技术，从DNA甲基化修饰途径探讨电针心经心包经对AD大鼠Aβ相关基因调控的表观机制，为“心-心相关经脉-脑（神明）的关系”这一中医原创理论的科学内涵提供全新阐释。

According to the original theory of ”Heart governs Mind” in TCM, heart-related meridians(HT and PC)have the advantage of treating the Mental disease.In the aging of the society,Alzheimer disease (AD)has attracted much attention as a public health problem in the world.The close relationship between epigenetic modification and AD has become a new focus of research.Researches in epigenetics show that Aβ aggregation is a key mechanism in the process of AD development and DNA methylation plays an important role in the regulation of gene expression in the generation, scavenging and toxicity of Aβ.Combined with the latest advances research and the previous research results of our research group, This project focuses on Aβ—the important target of AD，by needling the heart and pericardium meridians of AD models for intervention,targeting the key link of the regulation of gene expression in the generation,scavenging and toxicity of Aβ from methylation modification, exploring the regulatory mechanism of related genes expression of Aβ in the AD models from DNA methylation modification with the help of a series of advanced technology such as RNA-seq, Ch1P-seq and others related to molecular biology and neurobiology to provide new interpretations for this original theory of TCM “relationship among the heart, heart-related meridians and the brain”.