A Review on Characteristics of Experimental Research on Acupuncture Treatment for Alzheimer's Disease: Study Design.
A Review on Characteristics of Experimental Research on Acupuncture Treatment for Alzheimer's Disease: Study Design.
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DOI：
10.1155/2022/8243704
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发表时间：
2022
影响因子：
--
通讯作者：
Zhang, Wei
中科院分区：
文献类型：
--
作者：
Ke, Chao;Shan, Shengtao;Fang, Chuang;Xia, Yewan;Zhang, Wei
本文对近年来针灸治疗阿尔茨海默病的高质量动物研究成果进行了系统总结和分析。为今后的实验研究提供参考，为针灸治疗AD的临床应用提供实验依据。 我们使用及参考多个电子图书馆，自其成立至二零二一年十一月。查阅相关资料，提取期刊名称、发表记录、动物模型选择与制备、干预措施、穴位选择、检测方法、检测指标等信息。结果共选择了75项合格研究进行额外审查。雄性SAMP 8小鼠、APP/PS1双转基因小鼠、SD大鼠和Wistar大鼠是实验中常用的4种动物品系。动物被分类为转基因和外科手术小鼠模型。实验干预包括手针、电针、艾灸和电针加艾灸。20分钟的保留时间是实验研究的最佳时间，选择14个疗程作为最常见的治疗时间。电针是最常用的针灸治疗类型，连续波，2 Hz频率，1 mA电流被选为常用参数。共分析了78个穴位处方，涉及21个穴位。常用穴位组合前3位分别为GV 20 EX-HN 3、GV 20 EX-BL 23、GV 20 EX-GV 26。共有39篇文章有阳性药物对照组、假针刺和/或非穴位对照组。此外，10种行为测试，29种检测方法，178个评价指标和18个组织样本被纳入分析。 通过系统和全面地整理这些高质量的研究，针灸被认为是一种可行的和有效的治疗AD动物模型。此外，在设计实验时，研究人员可以参考这里提供的详细数据，以制定更好的方案，并可能在未研究的领域进行更多的调查。
This review aims to systematically summarize and analyze recent high-quality animal research results about the use of acupuncture in Alzheimer's disease (AD) patients. This information will be useful in providing a reference for future experimental research and an experimental basis for the clinical use of acupuncture in the treatment of AD. We utilized and referenced various electronic libraries from their inception to November 2021. Relevant information was reviewed and information such as the journal names, publication records, animal model selections and preparations, intervention measures, acupoint selections, detection methods, and detection indicators was extracted. Results. A total of 75 eligible studies were selected for additional review. Male SAMP8 mice, APP/PS1 double transgenic mice, Sprague–Dawley (SD) rats, and Wistar rats were the four commonly used animal strains in the experiments. The animals were categorized as transgenic and surgical mouse models. Experimental interventions included manual acupuncture (MA), Electro-acupuncture (EA), Moxibustion, and EA combined with Moxibustion. A retention time of 20 min was the optimal timing for experimental studies, with 14 sessions chosen as the most common treatment time. EA was the most prescribed acupuncture treatment type with continuous wave, 2 Hz frequency, and 1 mA electric current selected as frequently used parameters. A total of 78 acupoint prescriptions were analyzed involving 21 acupoints. The top 3 combinations of common acupoints were GV20 ⟶ EX-HN3, GV20 ⟶ BL23, and GV20 ⟶ GV26. A total of 39 articles had positive drug control groups, sham acupuncture, and/or nonacupoint control groups. Furthermore, 10 types of behavioral tests, 29 detection methods, 178 evaluation indicators, and 18 tissue samples were included in the analysis. By collating these high-quality research studies systematically and comprehensively, acupuncture was found to be a viable and effective treatment in AD animal models. In addition, when designing experiments, researchers could refer to the detailed data provided here to make better schemes and maybe conduct more investigations in unresearched areas.
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