系统性红斑狼疮（SLE）是典型的自身免疫病。其自身免疫复合物可促进动脉粥样硬化（AS）的形成，而由AS引发的心血管事件又是SLE死亡的主要原因。因此，有效防治SLE并发的AS是目前临床诊疗关键。前期相关研究发现狼疮定（LCD）具有增强糖皮质激素临床疗效、减轻类固醇性高脂血症的作用。因此，本项目拟在前期研究基础上，基于因虚生毒致瘀，从SLE自身抗体与AS形成的关系出发，利用具有SLE及AS倾向的gld apoE-/-小鼠及CRISPR/Cas9等基因编辑技术，研究LCD是否能通过抑制SLE抗内皮细胞抗体与抗氧化型低密度脂蛋白抗体对TLR4信号通路的协同激活，影响oxLDL内化，从而抑制SLE并发AS。研究结果对明确中医药抑制SLE并发AS的作用机制具有重要的科学价值，对丰富中医因虚生毒致瘀理论具有重要的理论价值，并将为寻找有效药物靶点、开发有效防治SLE新药奠定科学依据。

Systemic lupus erythematosus (SLE) is a typical autoimmune disease. Its autoimmune complex can promote the formation of atherosclerosis (AS), and cardiovascular events caused by AS are the main cause of death. How to effectively prevent and treat AS complicated with SLE is the key clinical issue at present. Our previous studies found that Langchuangding (LCD) could promote the clinical efficacy of glucocorticoid while relieving steroid-dependent hyperlipidemia. Therefore, based on the preliminary studies upon the relationship between SLE autoantibody and AS formation and the theory of blood stasis caused by toxic and deficiency of kindey, this study is aimed to investigate whether LCD could suppress the formation of SLE-related AS and the endocytosis on oxLDL IC of endothelial cells and macrophage by inhibiting the synergistic activation of AECA and oxLDL IC in SLE on the TLR4 signaling pathway, using spontaneous gld ApoE-/- model generated by gene editing techniques such as CRISPR/Cas9. This study will be valuable for understanding the role of TCM in inhibiting SLE complicated with AS, and in enriching the TCM theory of blood stasis caused by toxic and deficiency of kindey. It will also be greatly helpful for finding effective drug targets leading to the development of TCM for effective prevention and treatment on SLE.