肺炎支原体(MP)具有广泛致病性，是儿童肺炎重要病原之一。主要由MP脂质相关膜蛋白(LAMPs)介导黏附入侵，损伤细胞，诱导凋亡而导致肺损伤。清燥救肺汤临床疗效确切，实验研究发现能抑制肺部炎症，因而提出"燥热灼伤肺津与MP感染LAMPs模式识别及其通路调控存在一定相关性"假说。清燥救肺汤攻补兼施，内含清宣降润四法，以其有效物质群为切入点，采用单克隆抗体技术，结合HPLC-MS进行全方和分解剂药动学研究，探寻物质基础及作用靶器官。通过析因设计，以Balb/c小鼠MPP模型（有无外燥环境）为对象，采用Western-blot、RT-PCR等方法，观察LAMPs模式识别、NF-κB通路"元件"动态变化，阐明"燥热"、"肺津"现代生物指标内涵，探讨清燥救肺汤分解剂药能效果差异性，揭示改善MPP免疫炎性损伤的整合调节机制，为临床应用提供实验依据与理论支撑。

Mycoplasma pneumonia (M. pneumoniae) is one of the most common causes of pediatric pneumonia, with widespread and high pathogenicity. The adhesion and invasion was mainly mediated by M. pneumonia derived lipid-associated membrane proteins (LAMPs), which induced the apoptosis and pulmonary injury. Qingzao Jiufei (QZJF) decoction had an obvious effect in clinical practice and was confirmed that it was also effective on inhibiting inflammation spread in several experimental researches. Therefore, we proposed the hypothesis that there was correlation between dryness-heat injuring lung-yin and M. pneumonia derived LAMPs patten recognization and its regular pathway. QZJF decoction was tonification and purgation in combination, including four rules of clearing, ascending, desending and moistening. Begaining with active substance research, we combined the techniques of monoclonal antibodies with HPLS-MS pharmacokinetic study to explore material basics and target organ. Study was a factorial design. Balb/c mice infected by M. pneumonia were divided into exogenous dryness group and non-exogenous dryness group to observe LAMPs pattern recognization and dynamic change of components through NF-κB dependent-signal pathway with techniques of Western-blot, RT-PCR and so on. For providing research and theory basis, our study attempted to explore the content of dryness and lung fluid through modern biological indicators, to compare effectiveness of QZJF decoction and different decomposer and to discuss the mechanism of integrated regulation how QZJF decoction improved the immune pulmonary injury caused by M. pneumonia.