随着对癫痫发病机制研究的不断深入，致痫网络在癫痫发病中所起的作用日益受到重视，局灶性癫痫被认为是由于一侧或局部脑网络异常所引起。岛叶癫痫是局灶性耐药性癫痫的一种特殊类型，往往需要手术治疗。然而，由于岛叶癫痫临床表现复杂、难以与其他类型癫痫相区别，且有相当一部分患者在结构像MRI上无病灶，为进一步癫痫手术治疗带来极大困难。目前对于岛叶癫痫致痫网络特点仍然不甚清楚。本研究利用非侵入性影像学技术，将基于体素的形态学测量（VBM）技术与功能核磁共振、脑磁图相结合，利用形态测量分析技术（MAP）和图论分析方法，从结构及功能网络两个方面，多角度对岛叶癫痫致痫网络机制进行深入探索。并通过手术干预，结合手术预后、术后病理等指标，对致痫网络的特点进行验证，发现手术对致痫网络不同部位所产生的不同影响，揭示岛叶癫痫的致痫网络机制，力图为进一步侵入性检查及术前评估、手术预后提供新的影像学指标。

With the development of the research on the pathogenesis of epilepsy, epileptogenic network has been proposed to play an important role in this process. In the concept of epileptogenic network, focal epilepsy is considered as a result of abnormalities in a focal or lateral part of the brain. Insular epilepsy is a special type of drug-resistant focal epilepsy, accounting for a nonnegligible proportion of drug-resistant focal epilepsy, which needs to be surgically resected for most of the time. However, because of the following reasons, such as the complex clinical manifestations, mimic some other types of epilepsies, and lack of remarkable MRI lesions in some patients, the decision of surgery can be very difficult. So far, the characteristic of epileptogenic network in insular epilepsy is still unclear. This project is aimed at describing the characteristic of epileptogenic network in insular epilepsy by using non-invasive neuroimaging techniques including voxel-based morphometric (VBM) MRI postprocessing, functional MRI and magnetoencephalography (MEG), based on voxel-based MRI morphometric analysis program (MAP) and graph theory. Meanwhile, we will use surgical intervention to verify the epileptogenic network features and analyze the prognosis and postoperative pathology results to further explore the different effects of surgery on the different parts of the epileptogenic network. This project is intended to finally reveal the pathogenesis of the epileptogenic network in insular epilepsy, and try to provide new imaging indicators for further invasive examination, preoperative evaluation and postoperative prognosis.