IVF促排卵周期中注射hCG日孕酮升高可导致胚胎着床率显著降低，研究表明注射hCG日孕 酮升高可能损害了子宫内膜容受性，但确切的分子机制尚不清楚。本课题组前期研究发现注射hCG次日孕酮升高也可导致胚胎着床率显著下降。本课题拟首次在同时关注注射hCG日及次日 孕酮的基础上，研究孕酮升高对子宫内膜容受性的影响。基于已获得的初步结果，我们拟通 过多种技术手段验证：注射hCG日及次日高孕酮可能通过①导致腔上皮粘附功能损害；及② 诱导内膜腔上皮和腺上皮细胞基因表达的改变，进一步损害内膜容受性。本项目的研究结果 ，有利于增进对胚胎着床机制的深入了解，丰富子宫内膜免疫微环境的理论知识，为临床IVF 治疗策略的改变提供坚实的理论依据。

Increasing evidences have shown that premature elevated progesterone on the day of hCG administration was associated with reduced implantation rate in women undergoing IVF treatment, one possible explanation was due to the compromised endometrial receptivity. However, the exact molecular by which high progesterone acts on endometrial receptivity still remains elusive. We were able to confirm in our published previous study that elevated progesterone on the day after hCG administration was also negatively related to implantation rate. We firstly designed this research focusing on both consecutive progesterone measurements (on the day of, and day after hCG administration), to investigate the impact of elevated progesterone on endometrial receptivity. We’ve already obtained a certain primary results, and we’re planning to further investigate whether the adverse effects of high progesterone on endometrial reveptivity was ① partially mediated via its action on adhesion function of the luminal epithelial;and ② partially mediated via its modulation on the genomic profile and function of luminal epithelial and glandular compartment of endometrium. The findings of this research will help to update our knowledge on the mechanism of the implantation, to extend our understanding of the micro-environment of endometrium, and to provide robust evidences for the future changes of clinical treatments in practice.