经由金属卡宾的催化反应在有机合成化学中占有重要的地位，相关的不对称催化是构建手性结构的有效手段。不对称金属卡宾反应在过去的数十年里一直是人们关注的焦点，一大类高效、高选择性的不对称金属卡宾反应被发展起来。尽管这个领域已经被深入的研究，但是仍然有很多尚未得到解决的问题，一些最新发展的金属卡宾反应其相应的不对称催化仍未开展。本项课题将针对几类金属卡宾反应展开不对称催化的研究，包括经由叶立德的金属卡宾反应；基于卡宾过程的交叉偶联反应以及基于金属卡宾的高分子合成。期望通过这些研究发展新颖高效的不对称金属卡宾反应，为手性结构的构建提供新的策略和方法。

Catalytic reactions through metal carbene intermediate occupy an important position in organic synthesis. The corresponding asymmetric catalysis is a powerful method for the contraction of chiral structure. Catalytic asymmetric carbene reactions have attracted considerable attentions in the past decades, and a series of highly efficient and selective asymmetric carbene reactions have been developed. Although this area has been investigated in great details, there still remain unsolved problems, and the asymmetric catalysis of some newly developed carbene reactions has not been conducted. In this project, we will focus on the asymmetric catalysis of several metal carbene reactions, which include the reaction involving ylide intermediates, carbene-based cross-coupling reactions, and carbene-based polymerization. Through this project it is expected some highly efficient asymmetric metal carbene reactions will be developed, providing new strategies for the construction of chiral structures.