芳香硼酸（酯）是一类非常重要的化合物,在现代有机合成中得到十分广泛的应用。合成芳基硼酸酯的方法主要有：1）从芳基卤化物出发，首先制备格氏试剂或者锂试剂，再与三烷基硼酸酯反应；2）钯催化偶联的方法；3）铑、铱等过渡金属催化的碳氢键活化的方法。这些方法虽已被广泛应用，但均有各自的缺点，例如条件苛刻、官能团耐受性较差、催化剂较为昂贵，反应的选择性问题等等。鉴于芳香硼化合物的重要性，仍有必要发展这类化合物的合成方法。本项目将应用金、铁等过渡金属直接活化芳香碳氢键，并通过形成硼正离子等活化硼试剂，即通过双活化的手段实现新颖的芳香化合物的硼化。

Aromatic boronic acids or boronates are very important compounds, which have found wide applications in mordern organic synthesis. The main methods for the synthesis of aromatic boronic acids or boronates include: 1) from aromatic halides to prepare Grignard reagent, and then to react with alkyl borates; 2) Pd-catalyzed cross-coupling of arylhalides with diboron pinacol (Miyaura borylation); 3) transition-metal-catalyzed direct borylation of aromatic C-H bonds. Although these mothods have been widely applied in organic synthesis, they have some drawbacks, such as rigorous reaction conditions, functional group campatibility, expensive catalysts, and the regioselectivity of the reaction. Because of the importance of aromatic boron compounds, it is still highly desirable to develop new synthetic methods for these compounds. In this project, we will develop new borylation methods through Au- or Fe-catalyzed C-H bond functionalization by using highly reactive boron cation species.