IgAN是全世界常见的原发性肾小球肾炎之一，部分患者因肾纤维化10余年进展为终末性肾病，因此肾纤维化在IgAN进展占有重要地位，但是IgAN的肾纤维化的确切机制现在还不清楚。本课题组在前期预实验中发现IgAN患者血清血浆型gelsolin（plasma gelsolin,pGSN）下降最为明显，肾小球中pGSN含量明显增加且与TGF-β1和肾小球纤维化程度呈正相关，IgAN患者的这些结果在IgAN动物模型和pGSN处理系膜细胞后的表达谱的预实验中得到证实，由此推测pGSN可能参与IgAN肾小球的纤维化。pGSN和IgAN肾小球纤维化的关系，迄今国内外未见报道。本研究通过患者血清、肾组织及原代培养的系膜细胞，采用免疫学和分子生物学等手段探讨pGSN在IgAN肾小球纤维化的作用，明确其致纤维化机制，为选择药物治疗时机和预后预判奠定重要的实验基础。本研究具有重要的科学意义和潜在的应用价值。

IgA nephropathy（IgAN） is the most common form of progressive primary glomerulonephritis worldwide，the disease leads to end stage renal disease (ESRD) due to renal fibrosis in a substantial proportion of patients in more than ten years, therefore renal fibrosis plays an important role in the progress of IgAN, The mechanisms underlying renal fibrosis in IgAN remained unclear. In the preliminary experiments, we found that the plasma gelsolin (pGSN) in serum obviously decreased, the pGSN content in renal tissue increased significantly with positive correlation with TGF- β 1 and glomerular fibrosis degree in IgAN, the result was confirmed by the experimental animal models of IgAN and expression profiles after pGSN adminstration in mesangial cells, it suggests that pGSN may be involved in glomerular fibrosis in IgAN. The relationship between pGSN and glomerular fibrosis in IgAN has not reported now. Multiple levels including serum, renal tissue in patients and primary cultured mesangial cell, immunology and molecular biology in our research will be utilized to elucidate the role and molecular mechanism of pGSN in glomerular fibrosis in IgAN，whereby providing important experimental basis for the choice of medication time and judgement progrosis. This study has important scientific significance and potential application value.