妊娠期母体营养缺乏引发的胎儿宫内生长受限（IUGR）是一种普遍现象，它严重影响细胞周期和凋亡调控的绵羊胎儿肝脏细胞增殖生长发育模式而导致其生长减缓、发育缺陷，但其机理仍不很清楚。因此，本项目拟通过分析IUGR对蒙古绵羊胎儿肝脏生长发育、肝功能和肝脏细胞增殖生长发育模式影响的一般规律，测定IUGR胎儿肝脏细胞外生长因子及其受体表达和表观遗传变化，明确IUGR调控绵羊胎儿肝脏细胞增殖和凋亡的主效信号通路及其相互关系，研究IUGR绵羊胎儿肝脏细胞内主效信号通路对其细胞周期和凋亡的调控机理，从器官、细胞和分子的不同层次系统揭示IUGR绵羊胎儿肝脏细胞外生长因子及其受体-细胞内生长调控信号通路-细胞增殖与凋亡三位一体的分子调控信号网络，阐明IUGR导致绵羊胎儿肝脏细胞增殖生长发育模式及肝功能程序性改变的分子机理，为建立北方草原地区冬春季节合理科学的饲养管理制度以及医学该领域的研究提供一定的参考依据。

Intrauterine growth restriction induced by maternal undernutrition is a relatively common condition, which influences cell proliferation developmental pattern controled by the cell cycle and apoptosis severely, and results in compromise or disfigurement of growth and development of ovine fetal liver. However, the mechanisms remain unclear. Therefore, this study intends to analyze the effects of IUGR on growth and development, hepatic function, and cell proliferation developmental pattern of Mongolian ovine fetal liver, measure the concentrations of extracellular growth factors, the gene expressions and epigenetic modifications of their receptors in IUGR ovine fetal liver, determine the main cell signaling pathways regulating cell proliferation and apoptosis in IUGR fetal liver and their relationships, investigate the regulating mechanisms of the main cell signaling pathways in IUGR fetal liver to cell proliferation and apoptosis, aims to reveal the trinity molecular signal network of extracellular growth factors and their receptors - Intracellular growth regulating signaling pathways - cell proliferation and apoptosis, and clarify molecular mechanisms underlying the programming modifications of hepatic cell proliferation developmental pattern and functions in ovine fetus caused by IUGR, supply references for scientific feeding and management during the winter-spring grazing season of north China as well as the researches correlated in medical science.