不断升高的肥胖与哮喘发病率催生了一种特殊类型的哮喘—肥胖型哮喘，其不仅严重影响患者生活质量，还缺乏有效治疗手段。肥胖小鼠巨噬细胞炎性导致大量IL-1β分泌，进而活化ILC3分泌IL-17是肥胖型哮喘发病的重要机制。苓甘五味姜辛汤能够减轻哮喘患者症状，调低哮喘以及肥胖患者IL-1β表达，但是否对IL-1β介导的ILC3分泌IL-17具有调节作用及相关作用途径尚不清楚。故本研究拟在前期研究基础上，建立肥胖型哮喘模型，观察苓甘五味姜辛汤对该模型呼吸功能、肺组织病理表现、IL-1β- ILC3- IL-17通路的调节作用；通过体外培养ILC3，利用IL-1受体阻滞剂及重组IL-1β探索IL-1β介导ILC3活化在肥胖型哮喘中的作用以及苓甘五味姜辛汤对该环节的调节，综合分析苓甘五味姜辛汤治疗肥胖型哮喘的作用机制，为临床运用提供依据。

Rising incidence of obesity and asthma gave birth to a special phenotype of asthma - obese asthma, which seriously affecting patients’ life but without effective treatment. Obese asthma develops through a probably pathway involving secretion of IL-1β by macrophage actived in obese mice leads to an activating of ILC3, which secretes IL-17. Ling Gan Wuwei Jiang Xin Decoction can relieve symptoms of asthma, reduce expression of IL-1β in obesity and asthma, whether it can regulate IL-1β mediated IL-17 secretion by ILC3 in obese asthma is unclear. This study is to establish obese asthmatic models based on previous studies, observe the regulation role of Ling Gan Wuwei Jiang Xin Decoction through model respiratory function, lung tissue pathology and the adjustment on IL-1β-ILC3-IL-17 pathway, explore the probably pathway of IL-1β-mediated activation ILC3 of obese asthma and the regulation of Ling Gan Wuwei Jiang Xin Decoction by giving recombinant IL-1β and IL-1R antagonist on culture ILC3 in vitro, comprehensive analysis the treatment mechanism of Ling Gan Wuwei Jiang Xin Decoction on obese asthma, provide the basis for clinical use.