组织工程支架是种植细胞的场所和组织再生的模板。如何制备理想的三维组织工程支架，在组织工程领域引起了越来越多的关注。由于真空辅助树脂传递模塑(VARTM)/三维编织技术具有低加工成本性、生产工艺可重复性和产品制件形状设计的灵活性等优点，使其有望成为理想的高效率制备组织工程支架的新方法。 本项目将拓展VARTM/三维编织技术的应用领域，建立制备理想三维组织工程支架的新方法，探索成型新方法下三维组织工程支架的内部结构形态演变规律。通过泡孔结构形态的测试分析，研究不同工艺条件对组织工程支架的结构形态的影响，以及组织工程支架的制备工艺－结构－性能之间的关系。本项目旨在应用新方法制备获得新型的具有微管道且内部相互连通的理想三维组织工程支架，为细胞的种植和组织的再生提供良好的场所，在基础理论和应用领域都具有重要意义。

The tissue engineering scafflod is the matrix of seeding cells and repairing the tissues. How to fabricate the ideal three dimensional tissue engineering scaffolds has drawn more and more attention in tissue engineering fields. Due to the advantages of low-cost manufacturing, repeatability, and design flexibility, the Vacuum Assisted Resin Transfer Molding (VARTM)/3D braids technique could be an ideal and high efficiency processing method to fabricate tissue engineering scaffold. This project will expand the application area of VARTM/3D braid technique, establish a new approach to fabricate ideal 3D tissue engineering scaffold, explore the evolution rules of the internal structure morphology of 3D tissue engineering scaffold under the new manufacture method. The effects of different technological conditions on structure morphology of tissue engineering scaffold will be studied by testing, analysing the structure morphology of the pores. Moreover, the relationships among preparation technology, internal structure and property of tissue engineering scaffold will be analyzed. The novel ideal 3D tissue engineering scaffold with micro-channels and interconnectivity will be fabricated by using the new approach, and become the appropriate matrix for seeding cells and repairing the tissues.This researche has important significances on basic theory and application areas.