近年来通过直接的C sp3-H官能团化构建新的化学键已成为有机合成方法学研究的前沿和热点之一，大部分工作通过贵金属实现含氮化合物的C-H官能团化，如四氢异喹啉。但是关于氧原子邻位的官能团化研究较少，已有报道多集中在一些活泼亚甲基参与的反应，同时对于直接的不对称反应的研究也非常少。本研究期望利用非贵金属（如Fe、Cu）、有机氧化试剂（高价碘等）和脱氢试剂（如DDQ等）单独或共催化实现苄基醚类化合物的官能团化，高效、快速地实现一些含杂环骨架的构建，为该类化合物的不对称的引入提供新的最直接的方法及途径。通过本项目的实施，可以为氧原子α位的官能团化及活性化合物的合成提供新的思路及方法。

Recently the development of efficient methods towards carbon-carbon bond through the direct functionalization of sp3 C-H bond has become a growing area of investigation. Therefore the development of new synthetic strategy of sp3 C-H bond functionalization, especially unactived C-H bond, has become a significant and challenging area. Some endeavours were achieved to develop this powerful transformation using noble metals to afford formation od C-C, C-X bonds, especially tetrahydroquinoline derivatives. However, there are relatively few reports the sp3 O-C-H functionalization: successful cases were mostly concentrated in name organic reactions, and the range of substrates is also very limited. We wish to develop new synthetic strategy by using common metal, or organic oxidants, or dehydrogenated reagents, which will allow the efficient to construct oxygenous heterocylces. Finally we wish to apply the developed direct method in the asymmetric catalysis of benzylic ethers. It would also provide assistance and relief in the diversity-oriented synthesis, biological activity studies, and structure-activity relationship studies. Furthermore, it is hoped that the more efficient and effective application of the developed chemistry will improve the drug discovery process.