腰椎间盘突出后重吸收(RHLD)理论为保守疗法防治腰椎间盘突出症带来新的启示。特色回医烙灸治疗腰椎间盘突出症临床疗效确切，并能促进部分RHLD，降低腰椎间盘突出症的复发率，但作用机制不明。突出的髓核细胞凋亡在RHLD发挥重要作用。我们前期研究发现：烙灸可增加髓核细胞凋亡及髓核组织中IL-1和Caspase-3的表达。IL-1和Caspase-3是Fas/FasL信号通路上下游关键作用因子，激活该信号通路可促使髓核细胞凋亡，提出烙灸可能是介导Fas/FasL信号通路促进腰椎间盘突出后髓核重吸收的假说。本课题采用烙灸干预大鼠RHLD模型，主要研究：1.烙灸通过Fas/FasL通路对髓核细胞凋亡的调节机制；2.烙灸通过Fas/FasL通路对髓核细胞外基质的调控机制。验证烙灸介导Fas/FasL信号通路促进腰椎间盘突出后髓核重吸收的假说，阐明其作用机制，为烙灸防治腰椎间盘突出症提供理论和实验根据。

The Resorption of Herniated Lumbar Discs（RHLD）bring the new enlightenment for conservative treatment to cure lumbar disc herniation.How to promote RHLD is one of the key problems that need to solve conservative treatment.In Hui medicine, cautery moxibustion is one of the most effective treatments of lumbar disc herniation.The cautery moxibustion reduce the recurrence rate of lumbar disc herniation,but the mechanism of cautery moxibustion to treat RHLD can be expound. Apoptosis of nucleus pulposus cells is the major cause of RHLD.In our previous studies on rats, we have found that cautery moxibustion therapy can promote the apoptosis of nucleus pulposus cells,Caspase-3 and the IL-1 in the herniated lumbar discs.While IL-1 and Caspase-3 are key factors of the Fas/FasL signal pathways,and activating this pathway can increase the apoptosis of cartilage cells. In the present study，through analyzing the regulation of Fas/FasL signal pathway to the apoptosis of nucleus pulposus cells and the extracellular matrix of nucleus pulposus cells in herniated lumbar discs. Therefore the hypothesis that the cautery moxibustion possibly treats RHLD through mediating the Fas/FasL signaling pathway is proposed.In this study the model of cautery moxibustion intervention of rats’RHLD is adopted. Research contents:1. The mechanism of the cautery moxibustion influence multiplication and apoptosis of nucleus pulposus cells through mediating the Fas/FasL signaling pathway;2. The mechanism of the cautery moxibustion regulate the extracellular matrix of nucleus pulposus cells through mediating the Fas/FasL signaling pathway.The purpose of the study is to testify the hypothesis that the cautery moxibustion may treat RHLD through mediating Fas/FasL signaling pathway.The study lay the foundation for promotion of the cautery moxibustion.