钙调蛋白磷酸酶B亚基作为基因工程抗癌药物的作用机理研究

将钙调蛋白磷酸酶B亚基作为药物进行研究和开发是我们课题组的一个原创性工作。我们申请的"含有钙调蛋白磷酸酶B亚基的药物组合物"已授权国家发明专利和美国发明专利。在我们发现并由国家药物安评中心证实它的高抗癌药效和低毒性的基础上。本项目拟对rhCNB抗肿瘤药学机理、作用途径和与其相互作用蛋白和促凋亡等相关信号通路等进行较为深入的研究，为rhCNB成为一种临床药物打下坚实的基础。

It is Innovative work by our group to study and apply calcineurin B subunit (CNB) as drug. The patent "pharmaceutical composition containing calcineurin B subunit" have been authorized as Chinese inventive patent and USA inventive patent. Based on high anticancer effects and low toxicity of rhCNB detected by both national drugs safety evaluation center and us, this grant draws up to carry on anticancer mechanism and pharmic pathways of rhCNB , to search the important proteins relationship with the rhCNB in the signal transduction pathways relationship with apoptosis and cancer. These studies will provide the foundation in order to rhCNB become medicine