化学结构新颖、药理活性特异的海洋天然产物已经成为原创性药物的重要化合物来源。围绕国家开发“蓝色药库”的战略需求，针对海洋药物研发的药源瓶颈问题，课题组近年来开展了基于海洋化学生态学的药用生物资源发现与开拓研究。在前期研究中，发现具有显著抗藤壶幼虫附着活性的十四元大环内酯和氯代聚酮衍生物分别显示潜在的抗疟原虫和抗海分枝杆菌活性。本项目拟继续对具有抗疟和抗结核活性的化合物从化学结构多样性、化学结构优化、构效关系、分子对接及作用机制等方面进行深入系统的研究，以期发现具有自主知识产权的抗疟及抗结核药物先导化合物。

Marine natural products with structural novelty and unique biological activities have proven to be rich sources of chemical entities for drug discovery. Centering on the strategic requirements for national developing blue drug library and focusing on the drug bottleneck problem in marine drug research and development, our group has carried out the discovery and development of medicinal bioresources based on marine chemical ecology in recent years. In previous research, potent antifouling 14-memebered macrolides and chlorinated polyketides showed potential antimalarial and antimycobacterial activities, respectively. In current project, we propose to focus on structural diversity, structural optimization, structure-activity relationship, molecular docking and mechanism of action to discover and develop potent antimalarial and antimycobacterial drugs lead compounds with independent intellectual property rights.