海洋污损对海洋运输业、海洋工程以及海洋养殖业等行业带来巨大的经济损失，因此，研制环境友好、无毒的新型防污剂是国内外海洋研究热点领域之一。申请者从侧扁软柳珊瑚中发现了一系列具有显著抗海洋污损的活性化合物，从侧扁软柳珊瑚中分离获得3株共生菌，它们发酵的粗提物均具有较强抗海洋污损活性，依据共生菌与其宿主密切的共存依赖关系，本项目通过优化培养条件，应用天然产物化学以及分子生物学等多学科先进技术，以抗海洋细菌生物膜形成及抗大型海洋污损生物附着两个模型为筛选平台，对侧扁软柳珊瑚3株共生菌的抗海洋污损化合物进行分离、结构鉴定和抗污损活性研究，力争发现海洋防污剂或海洋防污剂先导化合物。

Marine biofouling has caused serious economic losses in various marine industries involving marine transportation, marine engineering and marine aquaculture. Therefore, searching for non-toxic environmentally friendly novel antifoulant is very urgent and becomes one of the main research focuses of the scientists worldwide. In the course of our investigation of bioactive compounds from the marine natural resources, we have identified series of novel compounds exhibiting significant antifouling activity from the South China Sea gorgonian coral Subergorgia suberosa. Interestingly, we also obtained three microorganisms from the coral Subergorgia suberosa with all of their fermentation extracts showing moderate antifouling activity. Based on the coexisted and mutually dependent relationship between the microbes and their host, in this proposal we will explore the bioactive compounds from the fermentation extracts of these three microorganisms by optimizing fermentation conditions, applying cutting-edge technologies in multidisciplinary fields with inhibiting both bacterial biofilm formation and fouling macroorganisms settlement as screening platforms, aiming at discovery of novel non-toxic antifoulant or its lead compound.