IMRT联合阿苯达唑壳聚糖微球对脊柱包虫病的影响研究

包虫病是一种感染了包虫幼虫而引起的慢性感染寄生虫病。脊柱是骨包虫的常见寄生部位，棘球坳开始位于脊髓腔内，生长缓慢,继而沿骨松质与骨孔蔓延，骨质破坏，引起病理性骨折。在治疗手段方面，手术仍然是治疗脊柱包虫病的首选方法，随着手术方法的改进及手术技能的提高，包虫病的临床治疗效果有了很大的提高，但术中包囊液及包虫溢漏会引起过敏性休克甚至死亡。苯丙咪唑类药物广泛的应用于包虫病的治疗，但是ABZ和MBZ 对于囊性包虫病的治愈率却仅为30%，原因可能与阿苯达唑在体内的吸收有限、局部血药浓度低及疗效欠稳定有关。近年来，以壳聚糖制成的阿苯达唑壳聚糖微球（ABZ-CS-MPs）在动物实验上取得了较新的成果。我们旨在构建小鼠活体内脊柱包虫的生物发光模型以监测定位和量化脊柱包虫的体内生长，以及IMRT联合 ABZ-CS-MPs在脊柱包虫治疗上的效果。我们期望能为脊柱包虫的临床治疗提供新的思路和方法。

Human hydatid disease (cystic echinococcosis, CE) is a chronic parasitic infection caused by the larval stage of the cestode Echinococcus granulosus.The spine is a common site of bone hydatid disease, Hydatid is located in the spinal cord cavity, slow growth, and then spread along the cancellous bone and bone pores, causing pathological fractures. In treatment, surgery is still the preferred method for the treatment of spinal hydatid disease, with improved surgical skills the clinical effect of the treatment of hydatid disease has been greatly improved, but the intraoperative cyst fluid and hydatid spill can cause anaphylactic shock and even death. Benzimidazole is widely used in the treatment of hydatid disease, but cure rate of ABZ and MBZ cystic hydatid disease was only 30%, for possible reasons the albendazole is unstable in vivo absorption, local blood drug concentration is low and the curative effect. In recent years, the Chitosan chitosan microspheres (ABZ-CS-MPs) made from chitosan have been successfully used in animal experiments. We aimed to construct an in vivo bioluminescence imaging mice model of bone hydatid to locate and quantify the presence of the parasites within specific organs (spine) noninvasively, and evaluate the effect of IMRT combined with ABZ-CS-MPs in bone hydatid disease. We intend to provide new ideas and methods for clinical treatment of bone hydatid disease.