近年来研究发现中性粒细胞胞外诱捕网络（NETs）形成在肿瘤进展中发挥着重要作用，NETs能够通过促进细胞外基质降解与血管形成等机制参与肿瘤细胞转移。以往研究证实在某些肿瘤患者如骨肉瘤中中性粒细胞释放NETs水平显著异常，但对于非小细胞肺癌（NSCLC）还不是十分清楚。我们前期研究发现NSCLC患者中性粒细胞释放NETs水平显著升高，且与肿瘤组织中IRF2BP2表达水平呈负相关，与血浆IL-8浓度呈正相关；随后的细胞学实验证实在NSCLC肿瘤细胞中下调IRF2BP2表达后IL-8水平显著升高，因此我们推测NSCLC患者肿瘤细胞IRF2BP2低表达引起IL-8表达升高，导致中性粒细胞释放NETs增加或NETs成分改变，通过降解细胞外基质、促进上皮间质化等过程参与非小细胞肺癌侵袭转移。本课题能够为理解非小细胞肺癌侵袭转移提供新的视角与思路，同时也为将来针对NETs靶点治疗提供相应的理论依据。

Recently, it has been found that neutrophil extracellular traps (NETs) played an important role in tumor progression. NETs can participate in cancer cell metastasis by promoting extracellular matrix degradation and angiogenesis. Previous studies have demonstrated that the release of NETs in some patients was significantly different such as osteosarcoma, but it remained unclear in patients with non-small cell lung cancer (NSCLC). Our preliminary study found that the release of NETs in NSCLC patients was significantly increased, which was negatively correlated with IRF2BP2 expression levels in tumor tissues and positively correlated with plasma IL-8 concentrations. Subsequent experiment suggested that downregulation of IRF2BP2 in NSCLC cancer cells could increase significantly IL-8 levels. Therefore, we speculated that low expression of IRF2BP2 in NSCLC patients could result in an increase in IL-8 expression, further leading to increased release of NETs or changes of NETs, eventually contributed to invasion and metastasis via promoting extracellular matrix degradation or epithelial-mesenchymal transition. This study can provide a new perspective for understanding invasion and metastasis of non-small cell lung cancer, and also could provide a theoretical basis for NETs targeted therapy in the future.