DNA 折纸术是DNA纳米技术发展的重要里程碑，其一方面带来了DNA设计的结构多样性，另一方面提供了纳米级可空间寻址性。DNA折纸术是DNA纳米结构研究的核心内容之一，如何基于DNA自组装发展结构最小折纸术，进而设计DNA纳米元器件，实现DNA纳米计算机是DNA纳米技术领域研究的一个重要问题。本项目拟基于DNA自组装从结构上发展更为灵活的最小折纸术，进而发展特定功能的DNA纳米器件及其在DNA纳米计算和肿瘤检测诊疗方面的应用，主要研究内容包括（1）基于DNA自组装的最小折纸术设计；（2）复杂空间结构的DNA折纸设计；（3）基于DNA折纸的纳米粒子排布分析；（4）DNA纳米元器件和机器的设计与应用。这方面研究不仅为基于DNA自组装技术发展更为灵活的最小折纸提供新方法，也为基于DNA纳米技术发展纳米DNA计算机、纳米数据存储方法等领域的应用提供技术支持

DNA origami is an important milestone in nanotechnology, which brings not only diversity of DNA sturctures, but also provides nanoscale addressabillty. How to develop minimal DNA origami and design DNA nano for DNA computing based on DNA Tile assemble strategy is a promising research branch in DNA nanotechnology. In this project, we plan to develop more flexible DNA origami tech, based on which particular functional DNA nano device with application in DNA nano computing and Tumor diagnosis may be obtained. The main contents of the project are as follows: (1) DNA assemble based DNA origami design; (2) design of DNA origami with complex spacial structure; (3) analysis of particles arrangement on DNA origami; (4) DNA origami based DNA nano devices and machine and their potential applications. The research can provide new ways to achieve flexible DNA origami with DNA tile assemble strategy, and also can give some technical support to the application of using DNA nanotechnology for DNA computing, nano data storage etc.