间脑A11多巴胺能神经元介导偏头痛的发生，支配整个中脑导水管周围灰质（PAG）。DRD2激动剂喹吡罗可抑制伤害性刺激诱发的三叉神经颈复合体神经元放电。CGRP与5-HT是目前偏头痛研究中证据最为充实的疼痛因子，A11对头痛的调控是否与CGRP和5-HT1B/1D相关？目前尚不明确。川芎-天麻是治疗头痛的有效药物，通过CGRP发挥治疗头痛作用，该作用是否通过A11多巴胺发挥？目前也不清楚。我们认为A11多巴胺能神经元通过多巴胺与CGRP、5-HT1B/1D的共存调控偏头痛痛觉，川芎-天麻可能通过A11多巴胺神经元发挥治疗头痛作用。为证实该假说，建立川芎-天麻预处理的间脑A11毁损偏头痛大鼠模型，观察DRD2与痛觉通路CGRP、5-HT1B/1D的相关性及PAG多巴胺cAMP-PKA通路蛋白的表达，阐述川芎-天麻可能通过A11多巴胺神经元发挥治疗头痛作用。此研究为偏头痛防治提供新思路和新靶点。

Diencephalon A11 dopaminergic neurons mediates migraine occurrence，it dominates the whole periaqueductal gray（PAG）. The DRD2 agonist quinpirole has inhibited firing of neurons in the trigeminocervical complex (TCC) induced by noxious pinch.CGRP and 5-HT are the migraine pain factor of the most substantial study evidence, the pain regulation of A11 dopamine cell groups in the diencephalon is associated with CGRP and 5-HT1B/1D? It is not clear.Chuanxiong-Tianma is recognized as the effective drugs to treat headache, playing treatment effect of headache through CGRP， whether through A11 dopamine?Is also unclear. We believe that the diencephalon A11 dopaminergic neurons had regulated migraine pain through the coexistence of the dopamine receptor and CGRP, 5-HT1B / 1D, Chuanxiong - Tianma may play treatment effect of headache through A11 dopamine neurons. To confirm this hypothesis, we had established Chuanxiong-Tianma pretreatment diencephalon A11 damaged rat model of migraine,observed correlation of DRD2 and pain pathway of CGRP, 5 - HT1B/1D of migraine rat and the midbrain aqueduct dopamine cAMP-PKA pathway protein expression for explaining Chuanxiong-Tianma to play treatment effect of headache through A11 dopamine neurons. This study is to provide new ideas and a new target for migraine prevention.