采用光镊实现对微纳米粒子的操控是当前研究的热点问题。光热微流光镊具有可调控性强、可操控范围较大、易于集成等优点。本项目将系统性的研究光热微流物理机理及对微纳米粒子操控，结合光流控芯片，提升拉曼光谱对微量物质的检测精度，包括：（1）利用多物理场耦合理论，研究光热微流物理机理；（2）研究光热波导对光热微流的调制机理；（3）研究光热微流对不同形貌微纳米颗粒的操控；（4）通过光热微流实现表面增强拉曼散射（SERS）衬底组装，提升拉曼光谱对水体中微量物质的检测精度。本项目针对水体高精度微量物质检测的共性基础问题，提出光热微流提升拉曼检测精度的新方法，有望促进水体高精度在线检测的发展。

Micro-/nano-particles manipulation by using optical tweezers is a research hotspot. Photothermal micro-fluidic optical tweezers have the advantages of strong controllability, large controllable range and easy integration. The project will systematically study on the physical mechanism of photothermal microfluidics and its manipulations on micro-/nano-particles. Combining with microfluidic chip, the detection accuracy of Raman spectroscopy for trace substances will be improved. The main work include that: (1) Study the physical mechanism of photothermal microfluidic by using the multi-physical field coupling thesis; (2) Study the modulation mechanism of photothermal microfluidic regulated by photothermal waveguide; (3) Modifications of micro-/nano-particles in fluid by using the optical tweezers of photothermal microfluidic; (4) Self-assembly of substrates for surface enhanced Raman scattering (SERS) by photothermal microfluidics, then improve the detection accuracy of substances in water by the method of Raman spectroscopy. Based on the common basic problems in detecting of trace materials in water, a new method of improving Raman detection accuracy by photothermal microfluidics is proposed, which is expected to promote the development of precision on-line detection in water environment.