调节性B细胞抑制咪喹莫特诱导的小鼠银屑病的免疫调节机制

银屑病是皮肤科常见的慢性炎症性自身免疫性疾病，确切的发病机制尚不明确。已有文献报道，应用B细胞清除疗法的患者出现银屑病样皮损，提示B细胞可能在银屑病发病中起着重要免疫调节作用。调节性B细胞（B10细胞）是近年备受关注的免疫调节细胞，主要通过产生白细胞介素-10（IL-10）发挥作用。在多种自身免疫性疾病的动物模型中都已证实，调节性B细胞具有负向免疫调节作用。本研究采用咪喹莫特诱导的银屑病动物模型，明确B细胞与调节性B细胞是否参与银屑病的发病，并阐明调节性B细胞在银屑病中的免疫调节作用及其机制。同时，探讨调节性B细胞对银屑病实验小鼠的抑制作用,为银屑病的治疗提供新的靶点。

Psoriasis is an autoimmune-ralated chronic inflammatory skin disease. Recently study indicated that psoriasis developed in patients after B cell depletion, suggesting that B cells may play an important role in the pathogenesis of psoriasis. Accumulating evidence proved that regulatory B cells (B10 cells), which belong to a specific B-cell subset, exert their regulatory role through the production of interleukin-10 (IL-10). Regulatory B cells negative regulation has been demonstrated in multiple autoimmunity mouse models. In this study, we will prove the relationship between B cells and B10 cells on the morbility of psoriasis by establishing imiquimod-induced psoriasis mouse modle elucidate the mechanisms of how impared B10 cells influence on imiquimod-induced inflammation reaction. In addition, we will explore the inhibition effect of B 10 cells on psoriasis mouse model. These will provide the exciting opportunities for treatment of psoriasis.