虎耳草属药用植物的功效、活性成分与分类群组、地理空间分布及生态环境的关联性研究

本课题组前期在对藏药"松蒂"的资源调查中发现，"松蒂"资源 90%以上来自于虎耳草属植物，篦齿虎耳草是其主流品种。进一步对篦齿虎耳草的化学研究发现了一类三萜皂苷类成分,这类成分在其他品种虎耳草研究中从未报道过,比如汉族地区的虎耳草品种。这提示了虎耳草属药用植物的不同分类群组及其所处地理空间、生态环境的不同可能导致其物质成分和功效的差异。经本草考证和文献查阅，发现①虎耳草属植物的现代化学和药效研究非常有限；②虎耳草属药用植物在汉族地区与藏族地区的医疗用途迥异；③虎耳草属植物的分类系统存在争议。本项目拟首次系统集成采用植物分类学、化学分类学、药效学等研究方法，从不同地域重点品种入手，考察我国虎耳草属药用植物整体，开展虎耳草属药用植物功效、活性成分与分类群组、地理空间分布及生态环境的关联性研究，从而揭示汉藏两地药用差异的深层原因，探讨虎耳草属植物的分类系统以及虎耳草属药用植物资源的保护与利用。

The preliminary work on the resources investigation of "Songdi"(Tibet medicine) revealed that the 90% resources of "Songdi" comes from Saxifraga and the main species of "Songdi" is S. umbellulata var. pectinata. A group of novel triterpenoid saponins was discovered by the further phytochemistry work on S.umbellulata var. pectinata, which has never been found in other species in Saxifraga, such as S. stolonifera, the main species distributed in Han Chinese regions. So, it is prompted that the various groups distributed in the different geographic space and ecological environment perhaps lead to the differences of chemical material composition and function. Therefore, for the first time, starting with the key species in different regions，a systematically integrated research method based on plant taxonomy, chemotaxonomy, pharmacodynamics and others is to be adopted to study the correlation between medicinal effect, active ingredients, groups, geographic spatial distribution and ecological environment of the whole China Saxifraga medicinal plant resources. Based on this integrated research, the discussions could be made on the deep reasons behind the functional differences between the medicinal Saxifraga resources in Han and Tibetan regions, the saxifraga classification system, and the conservation and utilization of medicinal Saxifraga plant resources.