呼吸是挥发性有机物（VOCs）人体暴露的主要途径。肺是VOCs直接危害的首要靶器官和进入人体的入口通道。肺泡液膜层是气-血屏障的主要构成部分，所含肺表面活性物质（PS）是调控肺泡表面张力、维持肺泡稳定、保障正常呼吸的关键物质。界面化学性质是PS功能的物理化学基础。VOCs与PS相互作用可改变PS界面化学性质，进而损伤肺功能，影响肺中VOCs的转运与转化。为查明VOCs与PS相互作用机理及其健康效应，拟从界面化学角度研究：1）VOCs暴露对PS呼吸相关活性的影响；2）VOCs暴露对PS界面化学性质的影响；3）VOCs在肺泡中的多相分配规律；4）VOCs跨肺泡液膜传质作用机理。成果着力解决VOCs损伤呼吸功能的界面化学机理、肺泡中VOCs迁移与归趋途径、VOCs跨肺泡液膜产生全身衍生危害的潜力等科学问题，为明确VOCs暴露与健康效应间因果关系，完善环境卫生标准，防治VOCs危害提供科学依据。

Respiration is a primary route of human exposure to Volatile Organic Compounds (VOCs). Lung is a foremost target organ of inhaled VOCs and is also the entrance by which VOCs enter human body. The alveolar lining fluid, an essential component of air-blood barrier, comprises Pulmonary Surfactants (PS), the vital matters that can stabilize alveoli by regulating the surface tension and then guaranteeing the normal pulmonary respiratory. The interfacial properties of PS are the physicochemical bases of functions of PS. The interactions between VOCs and PS would change the interfacial properties of PS and consequently impair the respiratory function of lung. Furthermore, the biotransport and biotransformation of VOCs in alveoli would inevitably be impacted by the interactions. For the purpose of ascertaining interaction mechanisms and their health effects, this project will investigate the following aspects by means of interfacial chemistry: 1) The influences of VOC exposure on the PS surface activity associated with respiratory function; 2) The influences of VOC exposure on interfacial properties of PS; 3) The partitioning of VOCs among multiphase of alveoli; 4) The mass transfer mechanisms for permeation of VOCs across the alveolar lining fluid layer. The project will attempt to solve the three scientific problems: 1) The interfacial chemical mechanisms for impairment of respiratory functions by VOCs; 2) The routes of the availability and fate of VOCs in alveoli; 3) The potentials of impairing the other organs by transportation of VOCs through alveoli lining layer. The prospective results will facilitate to comprehensively recognize the health effects of VOCs, to improve the environmental and health standards and to provide theoretical bases for the prevention of health hazards due to VOCs.