LncRNA SNHG8相关ceRNA网络调控HGF/c-Met通路介导子宫内膜癌发生发展的分子机制
结题报告
批准号:
81960471
项目类别:
地区科学基金项目
资助金额:
34.0 万元
负责人:
杨彩虹
依托单位:
学科分类:
肿瘤生物治疗
结题年份:
2023
批准年份:
2019
项目状态:
已结题
项目参与者:
杨彩虹
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中文摘要
子宫内膜癌(EC)是女性生殖系统常见的恶性上皮性肿瘤。lncRNA参与肿瘤的发生和发展,已成为癌症诊断和治疗的新靶点,其与EC的作用关系仍然值得探索。子宫内膜的基质细胞以肝细胞生长因子(HGF)自分泌增加的方式刺激内膜间质和上皮细胞增殖,HGF/c-Met信号传导的激活在EC发病机制中具有重要作用。课题组前期实验发现lncRNA SNHG8与EC生存期、淋巴结转移、临床分期呈正相关,SNHG8的过表达促进细胞增殖,反之亦然,且SNHG8与miR-152、c-Met的具有靶向结合关系。那么SNHG8是否通过ceRNA机制调控接头分子c-Met、Gab1,介导HGF/c-Met通路调控EC发生发展?本项目拟通过大样本回顾性分析SNHG8对于EC的临床相关性,并在细胞和动物模型中深入探讨SNHG8参与的ceRNA网络调控HGF/c-Met通路介导EC发生发展的作用方式和调控分子机制。
英文摘要
Endometrial cancer (EC) is a common malignancy of the female reproductive system. LncRNA is involved in the occurrence and development of tumors, and has become a new target for cancer diagnosis and treatment. The relationship between lncRNA and EC is still worth exploring. Endometrial stromal cells stimulate endometrial stromal and epithelial cell proliferation in the form of increased hepatocyte growth factor (HGF) secretion, and activation of HGF/ c-met signaling plays an important role in the pathogenesis of EC. Our previous experiments found that lncRNA SNHG8 was positively correlated with EC survival, lymph node metastasis and clinical staging, and that overexpression of SNHG8 promoted cell proliferation, and vice versa, and that SNHG8 had a targeted binding relationship with mir-152 and c-met. Then, SNHG8 regulate the development of joint molecules c-met and Gab1 through ceRNA mechanism, and mediate the regulation of EC by HGF/ c-met pathway? This project intends to retrospectively analyze the clinical relevance of SNHG8 to EC through a large sample, and further explore the action mode and molecular mechanism of SNHG8's participation in ceRNA network's regulation of HGF/ c-met pathway to mediate the occurrence and development of EC in cell and animal models
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DOI:--
发表时间:2022
期刊:宁夏医科大学学报
影响因子:--
作者:田雪敏;石璐璐;董 辉;杨彩虹
通讯作者:杨彩虹
DOI:--
发表时间:2023
期刊:宁夏医科大学学报
影响因子:--
作者:石璐璐;田雪敏;董 辉;杨彩虹
通讯作者:杨彩虹
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