艾滋病综合防控措施的优化组合、优先顺序、效果评价及各措施应维持在何种强度才能达到最大化减少艾滋病新发感染是当前国内外艾滋病防治研究中的重大难题。本研究拟在我国艾滋病流行最严重的广西地区，基于广西农村地区艾滋病流行态势与防控现状，建立包括多种有效防控措施在内的艾滋病传播动力学数学模型，通过现实数据的动态模拟和分析，利用组合优化及最优化控制数学理论解决有效防控措施组合策略优化的问题，提出综合防治措施组合下的优先顺序及各措施应维持在何种强度才能达到最大化减少艾滋病新发感染，解决当前数理模型研究局限于基本动力学数学理论或单个预防干预措施初步探讨，未做更进一步实际应用分析的缺陷。为政府部门决策提供科学依据，并开发出可视化的艾滋病防治辅助决策的计算机智能化系统。

Optimized combination, priority order, effect evaluation and what intensity of various prevention and control measures should be maintained for HIV/AIDS prevention and control, so that to maximize reduce HIV new infections is a major worldwide scientific problem in HIV/AIDS prevention and control. This study is to construct HIV/AIDS transmission dynamic mathematical model including a variety of effective prevention and control measures, which is based on current HIV epidemic and prevention & control situation in the most serious HIV epidemic area of Guangxi rural area in China. Using a combination of optimization and optimal control mathematical theory to solve the combined optimization strategy problem for effectively prevention and control of HIV transmission, we will conduct the dynamic simulation and analysis for real data and then make suggestions of the priority combination of comprehensive measures for HIV/AIDS prevention and control and calculate what intensity should be maintained then to maximum reduce HIV new infections through the analysis of mathematical model, so that it can resolve current scientific and public health problems which includes mathematical modeling focusing on basic mathematical kinetic theory or single prevention control measure, and no further study in practical application. The outcome of the study could provide scientific basis for government decision-making, and develop a computer intelligent system visualization and providing help to HIV/AIDS prevention and control decision-making.