SLC7A11高表达在肝癌发生发展中的作用及分子机制研究

肝癌已经严重危害我国国民的身心健康，深入研究肝癌的发病机制及调控机制并寻找相关的致癌基因，对开发早期诊断的检测指标和理想的治疗靶点至关重要。我们前期研究发现SLC7A11在肝癌组织中显著高表达，与肿瘤大小、预后不良正相关，并在五分之一AFP阴性肝癌组织中高表达，提示SLC7A11可能是一个潜在的致癌基因。为了深入研究SLC7A11与肝癌发生发展的关系，本研究拟开展以下工作：1）SLC7A11对肝癌细胞行为学的影响2）SLC7A11影响肝癌细胞生长和转移的信号通路研究。3）SLC7A11表达失调的分子机制研究。项目的完成将会阐明SLC7A11在肝癌发生发展中的作用及分子机制，为SLC7A11作为肝癌诊断标记物和以此为靶点开发新的治疗措施提供理论依据和实践经验。

Hepatocellular carcinoma (HCC)is a great danger to human health. The in-depth study the pathogenesis and regulation mechanisms of HCC is essential to find early diagnostic biomarks and ideal therapeutic targets. Our preliminary data show that SLC7A11 is up-regulated in hepatocellular carcinoma， promotes tumor growth leading to worse survival of patient,and up-regulated in the fifth AFP negative HCC. suggesting that SLC7A11 gene may play an important role in the hepatocarcinogenesis as an oncogene. In order to further evaluate the relationship of SLC7A11 with HCC development,we will study:1)The effects of SLC7A11 on HCC cellular behavior;2)The effects of SLC7A11 on cancer-associated signaling pathway;3)The molecular mechanism of SLC7A11 expression dysregulation. The study results will define the role and molecular mechanisms of SLC7A11 in the development and hepatocarcinomagenesis of HCC and providng supportive evidence for SLC7A11 as a early diagnostic biomark or new target for hepatocellular carcinoma therapy.