目前，炔烃和烯烃氢化胺化反应面临的最大挑战是提高催化剂的活性和反应的区域选择性。现在所用的催化剂中，铑和铂等价格昂贵，汞和铊等毒性大，而最好的钛和锆催化剂的活性有待提高。针对以上问题，结合我们多年的研究基础，在本次申请中，拟开展如下工作：（1）合成钛-稀土双金属化合物，将其用于催化炔烃的氢化胺化反应，利用金属核之间的"协同效应"，提高钛催化剂的活性。（2）用钛-稀土双金属化合物催化烯炔底物的氢化胺化反应、三组分和四组分串联反应、串联的氢化胺化和C-H活化反应，来合成多胺或含氮杂环，拓展氢化胺化反应在有机合成和天然产物合成中的应用。（3）合成锆-稀土双金属化合物，将其用于催化烯烃的分子内氢化胺化反应，利用"协同作用"，提高催化剂的活性。（4）合成含有[Zr+=N]基团的化合物，将其用于烯烃的氢化胺化反应。由于给活性基团[Zr=N]引入了正离子，使金属的Lewis酸性提高，从而提高催化活性。

The scientific research works we propose to carry out are summarized below. (1) Synthesize several heterobimetallic titanium -rare earth metal compounds and employ each heterobimetallic compound as the catalyst to catalyze the hydroamination reaction of alkynes, thus improving the catalytic activity of the catalyst by taking advantage of the "synergy effect" between the two metals.(2)Utilize each heterobimetallic compound to catalyze the hydroamination reaction of enyne substrates, three component and four component reactions, and tandem hydroamination and C-H activation reactions, therefore generating nitrogen-containing compounds and expanding the application of the hydroamination reaction in organic synthesis and natural product synthesis.(3)Synthesize the heterobimetallic zirconium-rare earth metal compounds and utilize the synthesized compounds to catalyze the intermolecular hydroamination reaction of alkenes, hence incearing the catalytic activity of the heterobimetallic complexes by using the "synergy effect" between the two metals.(4) Synthesize the complexes containing [Zr+=N] group and employ the complex as the catalyst for alkene hydroamination. The introduction of a cationic ion enhances the Lewis acidity of the metal center of the complexes, thereby improving the catalytic activity of the complexes.