超极化129Xe MR对早期COPD气血交换功能变化的定量研究

慢性阻塞性肺部疾病（COPD）是我国致残率第一的疾病，给众多家庭和国家造成了沉重的经济负担。然而，目前临床上的常规诊断方法，如肺功能检查、CT、胸透等，都不能无电离辐射、全面、定量和可视化地观测肺部气血交换功能，而此功能的评价对COPD疾病的诊断和预后有重要意义。本研究拟采用磁共振的前沿技术——超极化129Xe为气体MRI造影剂，发展新的磁共振脉冲序列（CSSR-DEPT）获得活体肺部气血交换动力学新数据，建立新的气血交换模型来无损、全面、定量地分析肺部交换功能的生理参数，以期能给COPD的早期诊断和治疗提供磁共振（MR）的新方法和新指标。

Chronic obstructive pulmonary disease (COPD) ranks first among the causes of disability in China, imposing a heavy economic burden on families and the country. The gas-blood exchange function, the evaluation of which is significant for the diagnosis and treatment of COPD, cannot be quantitatively and comprehensively measured using the traditional clinic diagnostic methods, such as pulmonary function tests (PFTs), computed tomography (CT) and X-ray, with non-invasion and non-ionization radiation. This project is intended to measure the pulmonary gas exchange function quantitatively and comprehensively in vivo using hyperpolarized xenon MR, in order to offer the new method and insights in diagnosing the early stage COPD with non-invasion and non-ionization radiation. To this aim, new MR pulse sequence to acquire the dynamics of the lung using hyperpolarized 129Xe with non-invasion and non-ionization radiation in vivo, and new pulmonary gas exchange model to extract the parameters of pulmonary gas exchange function quantitatively and comprehensively will be developed.