随着科技发展的不断进步以及对环境保护和社会可持续发展的要求，促使化学家们去发现更加简洁，高效，节能的合成方法。过渡金属催化的 C-H 键活化作为一种新的反应途径为我们提供了机遇和挑战。目前，C-H键活化已经取得了一些进展，但是不对称C-H键活化的研究仍然是一个全新的领域，在本科题的研究中，我们将利用过渡金属催化，通过亲电取代，氧化及卡宾插入等手段，通过不同配体调控，进一步系统探索不同种类的不对称 C-H 活化的途径，发展温和、高效的，具有普适性和选择性的新的不对称C-H 键活化新方法，认识和理解不对称C-H 键活化的一些新的机理和活化规律，为开拓此类研究在有机合成中的应用提供理论和实验基础，同时将发展的一些不对称C-H键活化反应方法应用到天然产物的合成当中。

Following the advancement of science and technology,environmental protection and social sustainable development. It's prompted chemists to discover more simple, higher efficient and energy conservation's methods. Transition metal-catalyzed C-H bond activation as one novel pathway afforded us chances and challenges. At present, C-H bond activation has achievied some advancements, but the asymmetric C-H bond activation is still a brand new area. In our project, we will use the transition metal catalysis, through the electronic substitution, oxidation, carbene insertion and chiral ligand control to searching different asymmetric C-H activation methods. We wished to develop some mild, higer efficient and general asymmmetric C-H activation methods and application to some natural products and pharmaceuticals sythesis. On this basis, we also wished to clarify some novel mechanisms involving in these reactions by captived useful intermediate and isotope reactions.