手性环己二烯-cis-二醇在天然产物和药物分子的合成中应用十分广泛。但是，到目前为止它只能通过生物合成得到。本项目拟通过2-吡喃酮的不对称催化Diels-Alder/逆Diels-Alder反应策略实现它们的不对称合成。在此基础上，我们将以这类手性环己二烯-cis-二醇化学为原料，实现具有高抗癌活性的石蒜科生物碱家族中一些重要成员和其类似物的高效全合成。另外，我们还将利用此策略实现手性环己二烯-cis-二胺、手性环己二烯-cis-氨基醇这类无法通过生物合成得到的重要手性合成砌块。

Chiral cyclohexadiene-cis-diol has been widely used in the synthesis of natural products and drug molecules. However, until now, it can only be obtained from biosynthesis. This project will achieve their chemical synthesis through the asymmetric catalytic Diels-Alder/retro-Deils-Alder reaction. Based on these results, by using these chiral cyclohexadiene-cis-diols as starting material, we will realize the highly efficient total synthesis of some family members of Amaryllidacease alkaloids and their analogs, which demonstrate great anticancer biological activities. Moreover, we will also apply this strategy to the synthesis of chiral cyclohexadiene-cis-diamine and cyclohexadiene-cis-amino alcohol that could not be obtained via biosynthesis.