针对男性HBV感染慢性化几率明显高于女性的现象，课题组在多年从事慢性肝病性别间差异机制和抗病毒治疗慢性病毒性肝炎影响因素研究的基础上，对曾于2010参加了本学科临床注册研究，并在本学科接受定期随访长达3年以上的患者进行性激素/性激素受体信号通路基因AKR1C3、AKR1C2、HSD17B6、ESR1和SRD5A1单核苷酸多态性分析。评价其在慢性HBV感染性别间的差异以及与疾病严重程度和抗病毒疗效间的关系。此外，还将在分析不同性别及不同临床表型慢性HBV感染者肝组织HBV受体NTCP表达特性的基础上，进一步探讨其在慢性HBV感染者性别间是否存在差异及其与性激素/性激素受体通路基因AKR1C3、AKR1C2、HSD17B6、ESR1和SRD5A1多态性的关系。希望能有所突破，能为慢性HBV感染在性别间差异机制的研究提供新的依据。

Males more easily suffered from chronic HBV infection and the concurrency rate of cirrhosis and primary hepatocellular carcinoma in male was higher than in female After infected with HBV,.The clinical outcome of sex disparity in chronic HBV infection has been recognized. At first, researchers focused on the effect of sex hormones. However exogenous hormones or hormone antagonist had not been found affected the progression of disease by animal experiment and the sex disparity of HBV infection was regard as sex hormones combined with sex hormone receptors activating the following signal pathway. But, papers published so far usually are cross sectional study with single liver biopsy of HCV infection and have not clinical data which is subject to a strong potential for reverse causation bias ,although the study analyzed the sex hormone pathway genetic polymorphism. Morever, study about the association between sex hormone pathway genetic polymorphism and sex disparity in chronic HBV infection has been not published. To further discuss the clinical outcome of sex disparity in chronic HBV infection, our group ,which had focused on the mechanism of sex disparity in chronic liver disease and antiviral therapy in chronic HBV/HCV infection, recruites patients following 3years in our register research after participating in the epidemiology registration study of chronic virus liver disease operated in 2010, and analyzes sex hormone/sex hormone receptor signaling pathway gene polymorphism of AKR1C3、AKR1C2、HSD17B6、ESR1 and SRD5A1. Then based on analyzing the expression of HBV receptor NTCP with different sex and different liver disease degree, our team will further discuss sex hormone/sex hormone receptor signaling pathway genetic polymorphism of AKR1C3、AKR1C2、HSD17B6、ESR1 and SRD5A1 and sex disparity. Hopefully new discovery and new proof to sex disparity in chronic HBV infection would be supplied by this study.