催化不对称合成是制备手性化合物的重要手段之一。与传统的催化剂相比，有机小分子催化剂具有环境友好和易于回收循环使用等一系列优势，在化工生产中极具应用前景。本项目以（硫）脲类催化剂为研究对象，利用其与Br?nsted酸协同催化，实现手性氰醇等化工生产中重要中间体的不对称合成。从结构和酸碱度可调的（硫）脲催化剂的设计和合成出发，本项目着重研究（硫）脲有机小分子与Br?nsted酸协同催化性能及手性传递规律，从实验和理论化学计算两方面揭示（硫）脲与Br?nsted酸协同催化中的关键调控因素，寻求改善立体选择性的方法和措施；探索结构和酸碱度对（硫）脲与Br?nsted酸协同催化效率的影响，从而最大程度地发挥协同催化不对称合成优势。该项目的研究成果可望为扩展和实现（硫）脲类催化剂在化工生产中的应用提供重要依据。

Asymmetric catalysis is one of the most important synthetic methods for chiral product. In comparison to traditional catalysts, organocatalyts have a series of advantages such as environmental friendliness, easy recycle and operation, rendering them a promising prospect in the paradigm of chemical industry. This study focus on (thio)urea catalysts, which can cooperatively catalyze the synthesis of important chiral chemical intermediate i.e. cyanohydrin with Br?nsted acid,. Based on the design and synthesis of novel (thio)urea catalysts with variable structures and acidities, this project aims to investigate cooperative (thio)urea-Br?nsted acid catalysis and its chiral relay, with an attempt to reveal the key regulatory factors of such catalytic system by means of experimental and theoretical methods. The changes of structure and acidity on the efficiency of cooperative (thio)urea-Br?nsted acid catalysis will also be studied to fully explore advantages of this cooperative catalysis system. The achievements are expected to provide a solid foundation for further application of (thio)urea catalysts in chemical industry.