炎症性肠病（IBD）是一种由肠道黏膜免疫系统异常引起的肠道炎症性疾病。白芍具有抗炎与免疫调节的功效，课题组前期发现麸炒白芍总苷可显著减轻IBD炎性症状，具有良好的抗IBD作用，但其作用机制尚不清楚。进一步研究发现，Th17/Treg平衡维持着肠道的生理性炎症，这一平衡的打破尤其是Th17的比例提高导致了肠道病理性炎症的发生；而IL-23/IL-17炎症轴继发性激活可进一步放大Th17/Treg失衡所致的炎症反应，导致IBD发病。鉴此，本课题提出假说：麸炒白芍总苷通过调节Th17/Treg平衡和IL-23/IL-17炎症轴发挥治疗IBD的作用。本项目拟采用IBD大鼠考察麸炒白芍总苷抗IBD的疗效，并结合体外细胞实验，探究麸炒白芍总苷对Th17/Treg平衡和IL-23/IL-17炎症轴的调节作用，揭示其抗IBD的作用机制。本研究有望阐明麸炒白芍抗IBD的药效物质基础，裨益白芍抗炎的临床治疗。

Inflammatory bowel disease (IBD) is an inflammatory bowel disease of anomaly caused by intestinal mucosal immune system. Radix Paeoniae Alba has anti-inflammatory and immunomodulatory effects, our previous study found that total glycosides in radix paeoniae alba after stir-baking with bran can significantly reduce inflammatory symptoms of IBD, has good anti IBD effect, but its mechanism is still not clear. Further study found that, Th17/Treg balance to maintain physiological intestinal inflammation, especially increase of proportion of Th17 can cause pathological intestinal inflammation; and IL-23/IL-17 axis activation can be further enlarged inflammation caused by the imbalance of Th17/Treg reaction, resulting in the pathogenesis of IBD. In view of this, we put forward the hypothesis: total glycosides in radix paeoniae alba after stir-baking with bran play a role in the treatment of IBD by regulating the balance of Th17/Treg and IL-23/IL-17 in inflammatory shaft. The project intends to establish a rat model of IBD and carry out an anti-IBD study, and combined with in vitro cell experiment, to explore total glycosides in bran Fried radix paeoniae alba’s effect on the regulation of Th17/Treg balance and IL-23/IL-17 inflammation axis. This project is expected to clarify the pharmacodynamic material basis of bran fried radix paeoniae alba anti-IBD effect and benefit the Radix Paeoniae Alba anti-inflammatory in clinical treatment.