探索刺激诱导超分子组装结构响应是一重要研究课题，持续探究此课题对推动国家纳米技术具有实质帮助。然而，关于进阶操控表面超分子结构的进展尚在启蒙阶段。申请人前期研究工作表明: 电场可影响分子于液固界面之组装行为，本立项依此基础，拟以具羧酸官能基的均苯三甲酸与其结构上的衍生物为研究素材，旨在探究电场极性结合外在调控参数，对有机分子组装结构受刺激后的响应机理，重点探索协同刺激效应理论。研究中扫描隧道显微镜为分析工具，同时扮演电场极性可调控刺激源；环境协同刺激参数包括: 调配系统溶剂极性、脉冲电位施加与控制组装结构环境温度等。初实验数据显示这些协同刺激效应具有定性、定量与选择性控制表面超分子混组装效果，其机理为提升或抑制羧酸官能基质子解离率，电渗力与卤素键等超分子系统将一并探讨,发掘一般性原则，机理将同时藉由理论计算诠释，预期立项成果将丰富与完善刺激诱导超分子组装结构响应理论，同时建立新颖技术平台。

The control of supramolecular assemblies is of great importance, paving the way toward future nanotechnology. In this context, stimuli-responsive systems present a research spotlight. However, such developments remain at the early stage. Proposed herein is an unprecedented idea namely a conceptual advance in the field of surface supramolecular chemistry. Specifically, we propose that multiple stimuli can be cooperatively used to tailor the outcomes of molecular self-assembly via synergic effect. In this study, the test-bed molecular systems are trimesic acid and its analogues. Scanning tunneling microscope (STM) plays a dual role in determining the electrical polarity and visualizing the changes of molecular assemblies simultaneously. Besides the electrical stimulations provided by STM, the cooperative sources in a system can be for example highly polar solvents, temperature, or electrical pulses. Preliminary results unambiguously show that such synergic stimuli allow one to utilize STM bias for efficiently and reversibly triggering molecular phase transformations in a quantitative, qualitative, and selective fashion, which would be otherwise inaccessible at the normal conditions (e.g., only by the selection of STM electrical polarity). The mechanism is tentatively proposed to be related to the biased tendency of (de)protonation of carboxylic acids in the targeted molecules treated by cooperative multi-stimuli. Mechanism that underpins the experimental results will be supported by computer simulations. We expected such studies embellish the field of supramolecular chemistry and meanwhile establish unique means to controlling molecular tectonics on solid surfaces.