基于胶体剂量计的光学CT法三维剂量验证技术，具有三维测量、高空间分辨的突出优势，但作为剂量读出的光学CT易受剂量计细微缺陷干扰，尽管双波长扫描模式具备改善成像质量潜质，但现有系统设计和差分式成像法尚未有效解决成像噪声高、伪影多问题，成为制约三维剂量测量精度、阻碍临床应用的重要因素。本项目以获取噪声低、伪影少的剂量图像为目标，从系统革新和方法学创新两方面入手，一方面，探究双波长系统设计中关键的波长选取原则和波长调制问题，提出先进双波长系统设计并搭建装置平台，另一方面，利用双波长扫描数据存在信息差异和模体连续运动特征，通过运动目标识别和轨迹预测，解决折射、反射等现象造成的缺陷特征随投影角度变化的问题，以此建立一种可对胶体剂量计缺陷做自适应修正的双波长光学CT成像新方法，配合先进装置平台，有效提高光学CT成像质量和剂量读取精度。预期的系统设计、装置平台和成像新方法，共同推动胶体剂量计临床实用化。

Gel dosimeters based optical-CT readout three-dimensional dose verification technology has the cutting-edge advantages of three-dimensional measurement and high-resolution. However, optical-CT is susceptible to gel dosimeter phantom impurities and defects. Although dual-wavelength scan is promising in image quality improvement, current scanner system design and the subtraction based imaging method is not robust enough yet and the readout dose images are easily degraded by noise and artifacts, which impacts the measurement precision and therefore hinders the clinical viability of gel dosimeters. In order to obtain dose images with reduced noise and artifacts, this study aims to optimize dual-wavelength optical-CT system design and propose a novel imaging method. First, this study explores the key issues of wavelength selection and modulation in system design optimization, and builds a prototype scanner as well. Then, based on the facts that dual-wavelength scanning channels provide different data information and that a gel phantom rotates continuously during data acquisition, object motion tracking and prediction technology in computer vision is adopted as the algorithm kernel to establish an adaptive phantom defects recognition and correction method, which is insensitive to the angular contrast variations of defects induced by reflection and refraction. The proposed system design and imaging method can synergize to improve optical-CT imaging quality and therefore dose readout precision. The delivered system design, prototype scanner and novel imaging method will boost the clinical viability of gel dosimeters.