基于主客体策略的化学发光超分子探针构建及在肾损伤检测中的应用研究

急性肾损伤（AKI）是临床常见的疾病，目前，全球每年因AKI而死亡的病人高达170余万，AKI已成为一个重大的健康问题。据研究表明，AKI的早期发展是可逆的，如果可以早期发现肾脏损伤并及时进行肾脏保护干预，以防止AKI演变成更严重的并发症，肾脏及其功能是可以恢复的。 然而，由于缺乏有效识别检测方法，目前临床诊断都是只能在肾脏发生不可逆的损伤后才能进行有效检测，难以实现AKI的早期预警与治疗。 针对这些问题，本项目拟通过设计合成高稳定和高发光效率的超分子化学发光成像平台，构建高灵敏度和高选择性的肾靶向化学发光ROS探针。通过探讨肾脏内ROS含量和肾损伤发展过程的相关性，建立可用于疾病发展程度研究的监测新方法。本项目有望为AKI的早期预警及检测提供新的手段，同时为研究药物疗效评估等应用基础研究领域提供有力工具。

Acute kidney injury (AKI) is a common clinical disease. At present, there is an estimated 1.7 million deaths per year globally due to AKI and AKI has become a significant health issue. According to research, the progression of AKI at an early stage is reversible, and the function of the kidney can be recovered if AKI is discovered and treated in a timely manner. However, due to the lack of effective identification and detection methods, the current clinical diagnosis can only monitor AKI after the kidney has an irreversible damage, and it is difficult to achieve early warning and treatment of AKI. In order to solve these problems, in this project, based on a supramolecular chemiluminescence imaging platform with high stability and high luminous efficiency, we intend to construct a high-sensitivity and selective kidney-targeted chemiluminescence ROS probe. By exploring the correlation between the ROS and the development of renal injury, we can establish a new monitoring method to study the degree of disease development. This project is expected to provide new means for early warning and detection of AKI, and may also provide a powerful tool for the evaluation of drug efficacy.